Acoustic priming and kanamycin-induced cochlear damage

James M. Tepper, Kurt Schlesinger

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The cochleae from 3 lines of mice, selectively bred for differential susceptibility to priming-induced audiogenic seizures, were examined following acoustic priming and retest or kanamycin treatment, and the degree of cochlear damage was assessed. After 60 sec of acoustic priming, animals from the high and unselected lines which had subsequently developed audiogenic seizure susceptibility exhibited severe cochlear damage limited to the outer hair cells. Low line mice, which had been selected for resistance to acoustic priming-induced audiogenic seizures and were not seizure susceptible, exhibited no cochlear pathology following acoustic priming. Following kanamycin treatment, all 3 lines developed subsequent audiogenic seizure susceptibility. Histological examination of cochleae from mice so treated revealed a pattern of damage similar to that caused by acoustic priming, except that the cochleae of priming-induced audiogenic seizure resistant low line mice revealed a significant amount of outer hair cell damage. The results are discussed with respect to the physiological mechanism underlying a selectively bred behavioral phenotype in terms of a possible instance of damage/disuse-supersensitivity in the central nervous system.

Original languageEnglish (US)
Pages (from-to)81-95
Number of pages15
JournalBrain research
Volume187
Issue number1
DOIs
StatePublished - Apr 7 1980
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • acoustic priming
  • auditory system
  • cochlear hair cell pathology
  • kanamycin
  • supersensitivity

Fingerprint

Dive into the research topics of 'Acoustic priming and kanamycin-induced cochlear damage'. Together they form a unique fingerprint.

Cite this