Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase

Jennifer Nielsen Kahn, Guillermo Garcia-Effron, Ming Jo Hsu, Steven Park, Kieren A. Marr, David S. Perlin

Research output: Contribution to journalArticlepeer-review

94 Scopus citations

Abstract

A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1. The resulting Phe655→Cys substitution altered the sensitivity of glucan synthase to echinocandin drugs, consistent with a common mechanism for echinocandin resistance in Candida spp.

Original languageEnglish (US)
Pages (from-to)1876-1878
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume51
Issue number5
DOIs
StatePublished - May 2007

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase'. Together they form a unique fingerprint.

Cite this