Activation of human T-cell leukemia virus type 1 Tax gene expression in chronically infected T cells

Hsin Ching Lin, Charlene S. Dezzutti, Renu B. Lal, Arnold B. Rabson

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Expression of human T-cell leukemia virus type 1 (HTLV-1) is regulated both by the HTLV-1 Tax transactival or and by cellular transcriptional factors binding to the viral long terminal repeat (LTR), suggesting that cellular signals may play a role in regulating viral expression. Treatment of cells chronically infected with HTLV-1, which express low levels of HTLV-1 RNAs and Tax protein, with phorbol esters (i.e., phorbol12-myristate 13- acetate [PMA]), phytohemagglutinin (PHA), sodium butyrate, or combinations of cytokines resulted in induction of HTLV-1 gene expression. PMA or PHA treatment following cotransfecfion of HTLV-1 Tax expression plasmids resulted in synergistic activation of HTLV-1 LTR-directed gene expression, apparently involving tyrosine kinase-mediated pathways. These results suggest that cellular activation stimuli may cooperate with HTLV-1 Tax to enhance expression of integrated HTLV-1 genomes and thus may play a role in the pathogenesis of HTLV-1 disease.

Original languageEnglish (US)
Pages (from-to)6264-6270
Number of pages7
JournalJournal of virology
Volume72
Issue number7
DOIs
StatePublished - Jul 1998

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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