Activation of immediate early genes after acute stress

Steven S. Schreiber; Georges Tocco; Tracey J. Shors; Richard F. Thompson

doi:10.1097/00001756-199101000-00004

Activation of immediate early genes after acute stress

Steven S. Schreiber, Georges Tocco, Tracey J. Shors, Richard F. Thompson

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

We used in-situ hybridization to study the effect of acute stress on induction of the immediate early genes (IEGs), c-fos and zif/268, in the rat brain. After one hour of restraint plus intermittent tail shock, messenger RNA (mRNA) levels for both genes were significantly increased bilaterally in the neocortex, particularly in layers IV, V and VI, and in the CA1 region of the hippocampus. This regionally-specific response suggests that IEGs may have a role in the mediation of acute stress responses in the central nervous system.

Original language	English (US)
Pages (from-to)	17-20
Number of pages	4
Journal	NeuroReport
Volume	2
Issue number	1
DOIs	https://doi.org/10.1097/00001756-199101000-00004
State	Published - Jan 1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

Acute stress
Immediate early genes
In-situ hybridization
Induction

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10.1097/00001756-199101000-00004

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AU - Tocco, Georges

AU - Shors, Tracey J.

AU - Thompson, Richard F.

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AB - We used in-situ hybridization to study the effect of acute stress on induction of the immediate early genes (IEGs), c-fos and zif/268, in the rat brain. After one hour of restraint plus intermittent tail shock, messenger RNA (mRNA) levels for both genes were significantly increased bilaterally in the neocortex, particularly in layers IV, V and VI, and in the CA1 region of the hippocampus. This regionally-specific response suggests that IEGs may have a role in the mediation of acute stress responses in the central nervous system.

KW - Acute stress

KW - Immediate early genes

KW - In-situ hybridization

KW - Induction

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Activation of immediate early genes after acute stress

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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