Activation of immediate early genes after acute stress

Steven S. Schreiber, Georges Tocco, Tracey J. Shors, Richard F. Thompson

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


We used in-situ hybridization to study the effect of acute stress on induction of the immediate early genes (IEGs), c-fos and zif/268, in the rat brain. After one hour of restraint plus intermittent tail shock, messenger RNA (mRNA) levels for both genes were significantly increased bilaterally in the neocortex, particularly in layers IV, V and VI, and in the CA1 region of the hippocampus. This regionally-specific response suggests that IEGs may have a role in the mediation of acute stress responses in the central nervous system.

Original languageEnglish (US)
Pages (from-to)17-20
Number of pages4
Issue number1
StatePublished - Jan 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)


  • Acute stress
  • Immediate early genes
  • In-situ hybridization
  • Induction


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