Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): Interaction with other regulatory ligands

Lai Hua Xie, Scott A. John, Bernard Ribalet, James N. Weiss

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations

Abstract

All members of the inwardly rectifying potassium channels (Kir1-7) are regulated by the membrane phospholipid, phosphatidylinosital-4,5-bisphosphate (PIP2). Some are also modulated by other regulatory factors or ligands such as ATP and G-proteins, which give them their common names, such as the ATP sensitive potassium (KATP) channel and the G-protein gated potassium channel. Other more non-specific regulators include polyamines, kinases, pH and Na+ ions. Recent studies have demonstrated that PIP2 acts cooperatively with other regulatory factors to modulate Kir channels. Here we review how PIP2 and co-factors modulate channel activities in each subfamily of the Kir channels.

Original languageEnglish (US)
Pages (from-to)320-335
Number of pages16
JournalProgress in Biophysics and Molecular Biology
Volume94
Issue number3
DOIs
StatePublished - Jul 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Molecular Biology

Keywords

  • Co-factors
  • Kir channels
  • PIP
  • Regulation

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