Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): Interaction with other regulatory ligands

Lai Hua Xie; Scott A. John; Bernard Ribalet; James N. Weiss

doi:10.1016/j.pbiomolbio.2006.04.001

Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP₂): Interaction with other regulatory ligands

Lai Hua Xie, Scott A. John, Bernard Ribalet, James N. Weiss

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

All members of the inwardly rectifying potassium channels (Kir1-7) are regulated by the membrane phospholipid, phosphatidylinosital-4,5-bisphosphate (PIP₂). Some are also modulated by other regulatory factors or ligands such as ATP and G-proteins, which give them their common names, such as the ATP sensitive potassium (K_ATP) channel and the G-protein gated potassium channel. Other more non-specific regulators include polyamines, kinases, pH and Na⁺ ions. Recent studies have demonstrated that PIP₂ acts cooperatively with other regulatory factors to modulate Kir channels. Here we review how PIP₂ and co-factors modulate channel activities in each subfamily of the Kir channels.

Original language	English (US)
Pages (from-to)	320-335
Number of pages	16
Journal	Progress in Biophysics and Molecular Biology
Volume	94
Issue number	3
DOIs	https://doi.org/10.1016/j.pbiomolbio.2006.04.001
State	Published - Jul 2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Molecular Biology

Keywords

Co-factors
Kir channels
PIP
Regulation

Access to Document

10.1016/j.pbiomolbio.2006.04.001

Cite this

@article{4813999e854d40eba4f706d139ef2ac7,

title = "Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): Interaction with other regulatory ligands",

abstract = "All members of the inwardly rectifying potassium channels (Kir1-7) are regulated by the membrane phospholipid, phosphatidylinosital-4,5-bisphosphate (PIP2). Some are also modulated by other regulatory factors or ligands such as ATP and G-proteins, which give them their common names, such as the ATP sensitive potassium (KATP) channel and the G-protein gated potassium channel. Other more non-specific regulators include polyamines, kinases, pH and Na+ ions. Recent studies have demonstrated that PIP2 acts cooperatively with other regulatory factors to modulate Kir channels. Here we review how PIP2 and co-factors modulate channel activities in each subfamily of the Kir channels.",

keywords = "Co-factors, Kir channels, PIP, Regulation",

author = "Xie, {Lai Hua} and John, {Scott A.} and Bernard Ribalet and Weiss, {James N.}",

note = "Funding Information: This work was supported by a NIH Grant R37HL60025, and Laubisch and Kawata Endowments to J..N.Weiss, and by a Scientist-Development-Grant from the American Heart Association (National Research Center) to L.-H. Xie. ",

year = "2007",

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doi = "10.1016/j.pbiomolbio.2006.04.001",

language = "English (US)",

volume = "94",

pages = "320--335",

journal = "Progress in Biophysics and Molecular Biology",

issn = "0079-6107",

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T1 - Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2)

T2 - Interaction with other regulatory ligands

AU - Xie, Lai Hua

AU - John, Scott A.

AU - Ribalet, Bernard

AU - Weiss, James N.

N1 - Funding Information: This work was supported by a NIH Grant R37HL60025, and Laubisch and Kawata Endowments to J..N.Weiss, and by a Scientist-Development-Grant from the American Heart Association (National Research Center) to L.-H. Xie.

PY - 2007/7

Y1 - 2007/7

N2 - All members of the inwardly rectifying potassium channels (Kir1-7) are regulated by the membrane phospholipid, phosphatidylinosital-4,5-bisphosphate (PIP2). Some are also modulated by other regulatory factors or ligands such as ATP and G-proteins, which give them their common names, such as the ATP sensitive potassium (KATP) channel and the G-protein gated potassium channel. Other more non-specific regulators include polyamines, kinases, pH and Na+ ions. Recent studies have demonstrated that PIP2 acts cooperatively with other regulatory factors to modulate Kir channels. Here we review how PIP2 and co-factors modulate channel activities in each subfamily of the Kir channels.

AB - All members of the inwardly rectifying potassium channels (Kir1-7) are regulated by the membrane phospholipid, phosphatidylinosital-4,5-bisphosphate (PIP2). Some are also modulated by other regulatory factors or ligands such as ATP and G-proteins, which give them their common names, such as the ATP sensitive potassium (KATP) channel and the G-protein gated potassium channel. Other more non-specific regulators include polyamines, kinases, pH and Na+ ions. Recent studies have demonstrated that PIP2 acts cooperatively with other regulatory factors to modulate Kir channels. Here we review how PIP2 and co-factors modulate channel activities in each subfamily of the Kir channels.

KW - Co-factors

KW - Kir channels

KW - PIP

KW - Regulation

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