Activation of Meiotic Genes Mediates Ploidy Reduction during Cryptococcal Infection

Youbao Zhao, Yina Wang, Srijana Upadhyay, Chaoyang Xue, Xiaorong Lin

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Zhao et al. show that meiosis genes facilitate ploidy reduction in the global fungal pathogen Cryptococcus neoformans, and they are activated during infection. Progeny isolated from the host that have meiotic genes activated show increased resistance to specific genotoxic stress, indicating the occurrence of meiosis may empower adaptative mutations.

Original languageEnglish (US)
Pages (from-to)1387-1396.e5
JournalCurrent Biology
Issue number8
StatePublished - Apr 20 2020

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences


  • Cryptococcus
  • DSBs
  • Dmc1
  • Rec8
  • meiosis
  • pathogenesis
  • phenotypic diversity
  • ploidy reduction
  • polyploidization
  • unisexual reproduction


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