@article{6eaa78be9a30439ab96d1caeba584b10,
title = "Activation of Meiotic Genes Mediates Ploidy Reduction during Cryptococcal Infection",
abstract = "Zhao et al. show that meiosis genes facilitate ploidy reduction in the global fungal pathogen Cryptococcus neoformans, and they are activated during infection. Progeny isolated from the host that have meiotic genes activated show increased resistance to specific genotoxic stress, indicating the occurrence of meiosis may empower adaptative mutations.",
keywords = "Cryptococcus, DSBs, Dmc1, Rec8, meiosis, pathogenesis, phenotypic diversity, ploidy reduction, polyploidization, unisexual reproduction",
author = "Youbao Zhao and Yina Wang and Srijana Upadhyay and Chaoyang Xue and Xiaorong Lin",
note = "Funding Information: We thank Beth Richardson and Dr. John Shields at the Georgia Electron Microscopy laboratory for SEM analyses, Julie Nelson at the UGA Cytometry Shared Resource laboratory for her help with flow cytometry analysis using the CyAn ADP cell analyzer (NIH grant 1S10RR027814), and Dr. Wendy Watford for her help with γ-irradiation. We thank Drs. Douda Bensasson, Ence Yang, Alexander Idnurm, Joseph Heitman, Bing Zhai, and the Lin lab members for their input on this project. This work was supported by the National Institutes of Health (R21AI132125 and R01AI140719 to X.L. and R01AI123315 to C.X.) and the University of Georgia (fund to X.L.). X.L. holds an Investigator Award in the Pathogenesis of Infectious Disease from the Burroughs Wellcome Fund (1012445). The funders had no role in study design, data collection, and interpretation, or the decision to submit the work for publication. Conceived and designed the experiments, Y.Z. and X.L.; Performed the experiments, Y.Z. Y.W. S.U. and C.X.; Analyzed the data and wrote the paper, Y.Z. C.X. and X.L. The authors declare no competing interests. Funding Information: This work was supported by National Institutes of Health (R21AI132125 and R01AI140719 to XL and R01AI123315 to CX) and the University of Georgia (fund to XL). Dr. Lin holds an Investigator Award in the Pathogenesis of Infectious Disease from the Burroughs Wellcome Fund (1012445). The funders had no role in study design, data collection, and interpretation, or the decision to submit the work for publication. Funding Information: We thank Beth Richardson and Dr. John Shields at the Georgia Electron Microscopy laboratory for SEM analyses, Julie Nelson at the UGA Cytometry Shared Resource laboratory for her help with flow cytometry analysis using the CyAn ADP cell analyzer ( NIH grant 1S10RR027814 ), and Dr. Wendy Watford for her help with γ-irradiation. We thank Drs. Douda Bensasson, Ence Yang, Alexander Idnurm, Joseph Heitman, Bing Zhai, and the Lin lab members for their input on this project. This work was supported by the National Institutes of Health ( R21AI132125 and R01AI140719 to X.L. and R01AI123315 to C.X.) and the University of Georgia (fund to X.L.). X.L. holds an Investigator Award in the Pathogenesis of Infectious Disease from the Burroughs Wellcome Fund ( 1012445 ). The funders had no role in study design, data collection, and interpretation, or the decision to submit the work for publication. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2020",
month = apr,
day = "20",
doi = "10.1016/j.cub.2020.01.081",
language = "English (US)",
volume = "30",
pages = "1387--1396.e5",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Cell Press",
number = "8",
}