Activation of Meiotic Genes Mediates Ploidy Reduction during Cryptococcal Infection

Youbao Zhao, Yina Wang, Srijana Upadhyay, Chaoyang Xue, Xiaorong Lin

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Zhao et al. show that meiosis genes facilitate ploidy reduction in the global fungal pathogen Cryptococcus neoformans, and they are activated during infection. Progeny isolated from the host that have meiotic genes activated show increased resistance to specific genotoxic stress, indicating the occurrence of meiosis may empower adaptative mutations.

Original languageEnglish (US)
Pages (from-to)1387-1396.e5
JournalCurrent Biology
Volume30
Issue number8
DOIs
StatePublished - Apr 20 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Keywords

  • Cryptococcus
  • DSBs
  • Dmc1
  • Rec8
  • meiosis
  • pathogenesis
  • phenotypic diversity
  • ploidy reduction
  • polyploidization
  • unisexual reproduction

Fingerprint Dive into the research topics of 'Activation of Meiotic Genes Mediates Ploidy Reduction during Cryptococcal Infection'. Together they form a unique fingerprint.

  • Cite this