Active viral B hepatitis in parenteral drug abusers with acquired immune deficiency syndrome (AIDS).

C. B. Leevy, H. Nurse, Rajendra Kapila

Research output: Contribution to journalArticle

Abstract

Eighty-percent of 47 parenteral drug abusers with hepatomegaly and acquired immunodeficiency syndrome had HBV DNA in serum, although only 27% were HBsAg or "e" antigen-positive by polyclonal radioimmunoassay. Liver biopsies from each of 37 HBV DNA seropositive patients showed HBV DNA and were HBcAg-positive. The absence of positive HBsAg and "e" antigen in HBV DNA-positive patients was attributable to the presence of immune complexes; after in vitro dissociation of these complexes there was an increase in HBsAg from 24% to 86%, and of "e" antigen from 19% to 62%. These data indicate that actively replicating hepatitis B virus is common in patients with AIDS, and that precautions should be taken to prevent its dissemination. Therapy in these patients should address both human immunodeficiency and hepatitis B virus infections.

Original languageEnglish (US)
Pages (from-to)18-19, 22
JournalJournal of the Association for Academic Minority Physicians : the official publication of the Association for Academic Minority Physicians
Volume1
Issue number1
StatePublished - Dec 1 1989

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Drug Users
Hepatitis B
Hepatitis B e Antigens
Acquired Immunodeficiency Syndrome
Hepatitis B Surface Antigens
DNA
Hepatitis B virus
Hepatitis B Core Antigens
Hepatomegaly
Virus Diseases
Antigen-Antibody Complex
Radioimmunoassay
Biopsy
Liver
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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