Acute and chronic effects of ginseng total saponin and amphetamine on fixed-interval performance in rats

A. K. Halladay, Y. L. Yu, J. Palmer, K. W. Oh, G. C. Wagner

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The effect of ginseng total saponin (GTS) on amphetamine (AMPH)-induced disruption of fixed-interval (FI) responding in rats was examined. GTS (50 mg/kg) significantly improved the temporal responding impaired by 2 mg/kg of AMPH. A higher dose of 100 mg/kg GTS disrupted performance when given alone; this disruption was reversed by a low dose of AMPH (0.5 mg/kg) and tolerance developed to the effects of GTS with its repeated administration. Neurochemical analysis revealed that GTS (50 mg/kg) attenuated the increase in striatal dopamine caused by AMPH leading to the conclusion that brain dopamine may partially mediate the behavioral effects of GTS.

Original languageEnglish (US)
Pages (from-to)162-164
Number of pages3
JournalPlanta Medica
Volume65
Issue number2
DOIs
StatePublished - 1999

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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