TY - JOUR
T1 - Acute changes in heart rate variability in subjects with diabetes following a highway traffic exposure
AU - Laumbach, Robert J.
AU - Rich, David Q.
AU - Gandhi, Sampada
AU - Amorosa, Louis
AU - Schneider, Stephen
AU - Zhang, Junfeng
AU - Ohman-Strickland, Pamela
AU - Gong, Jicheng
AU - Lelyanov, Oleksiy
AU - Kipen, Howard M.
N1 - Funding Information:
This study was funded by NIEHS Center ES005022 , K08 ES135202 , and USEPA STAR R832144 .
PY - 2010/3
Y1 - 2010/3
N2 - Objective: To pilot a protocol to evaluate acute cardiovascular effects in in-vehicle exposure to traffic air pollutants in people with diabetes. Methods: Twenty-one volunteers with type 2 diabetes were passengers on 90- to 110-minute car rides on a busy highway. We measured in-vehicle particle number and mass (PM2.5) nitrogen dioxide, and carbon monoxide and heart rate, heart rate variability (HRV), and blood pressure. Results: Compared with pre-ride measurements, we found a decrease in high frequency (HF) HRV from pre-ride to next day (ratio 0.66, 95% CI = 0.47 to 0.93) and an increase in low frequency to HF ratio at post-ride (ratio 1.92, 95% CI = 1.21 to 3.05) at post-ride. Interquartile range increases in measured pollutants were associated with next-day decreases in HR HRV. Conclusions: This protocol appears useful for assessing acute adverse cardiovascular effects of in-vehicle exposures among people who have diabetes.
AB - Objective: To pilot a protocol to evaluate acute cardiovascular effects in in-vehicle exposure to traffic air pollutants in people with diabetes. Methods: Twenty-one volunteers with type 2 diabetes were passengers on 90- to 110-minute car rides on a busy highway. We measured in-vehicle particle number and mass (PM2.5) nitrogen dioxide, and carbon monoxide and heart rate, heart rate variability (HRV), and blood pressure. Results: Compared with pre-ride measurements, we found a decrease in high frequency (HF) HRV from pre-ride to next day (ratio 0.66, 95% CI = 0.47 to 0.93) and an increase in low frequency to HF ratio at post-ride (ratio 1.92, 95% CI = 1.21 to 3.05) at post-ride. Interquartile range increases in measured pollutants were associated with next-day decreases in HR HRV. Conclusions: This protocol appears useful for assessing acute adverse cardiovascular effects of in-vehicle exposures among people who have diabetes.
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U2 - 10.1097/JOM.0b013e3181d241fa
DO - 10.1097/JOM.0b013e3181d241fa
M3 - Article
C2 - 20190650
AN - SCOPUS:77949451443
SN - 1076-2752
VL - 52
SP - 324
EP - 331
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
IS - 3
ER -