Abstract
Alcohol abuse and cigarette smoking have been on the rise worldwide and it has been reported that alcohol and nicotine influence serotonergic neuronal activity in the dorsal raphe. Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of various neuropsychiatric disorders. In the present study, the effects of alcohol and nicotine on the synthesis of 5-HT and the expression of tryptophan hydroxylase (TPH), the rate limiting enzyme of 5-HT synthesis, in the dorsal and median raphe of young rats were investigated via immunohistochemistry. The numbers of the 5-HT-positive and TPH-positive cells in raphe nuclei were reduced by alcohol and nicotine treatment, and these numbers were reduced more potently by co-administration of alcohol and nicotine. Based on the results, it can be suggested that the pathogenesis of alcohol- and nicotine-induced neuropsychological disorders involves alcohol- and nicotine-induced suppression of 5-HT synthesis and TPH expression in raphe, and that this may be of particular relevance in the consumption of alcohol and nicotine during adolescence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5-8 |
| Number of pages | 4 |
| Journal | Korean Journal of Physiology and Pharmacology |
| Volume | 7 |
| Issue number | 1 |
| State | Published - Feb 2003 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Physiology
- Pharmacology
Keywords
- 5-Hydroxytryptamine
- Adolescence
- Alcohol
- Dorsal raphe nuclei
- Median raphe nuclei
- Nicotine
- Tryptophan hydroxylase