Acute haloperidol increases impulse activity of brain noradrenergic neurons

Timothy G. Dinan; Gary Aston-Jones

doi:10.1016/0006-8993(84)90495-5

Acute haloperidol increases impulse activity of brain noradrenergic neurons

Timothy G. Dinan, Gary Aston-Jones

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Haloperidol (0.5 mg/kg, i.p.) increased impulse activity of every noradrenergic locus coeruleus neuron tested in chloral hydrate anesthetized rats. Mean discharge rate increased from 1.4 ± 0.2 Hz before to 2.7 ± 0.4 Hz at 45 min after injection, with significantly increased activity occurring by 15 min post-drug. Elevated activity was apparent for at least 2 h following haloperidol. These results reveal that haloperidol has profound effects on brain noradrenergic neurons, indicating a possible site of action for effects of this neuroleptic agent.

Original language	English (US)
Pages (from-to)	359-362
Number of pages	4
Journal	Brain research
Volume	307
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(84)90495-5
State	Published - Jul 30 1984
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Keywords

haloperidol
locus coeruleus
neuroleptics
norepinephrine
pharmacogenic depression
unit recordings

Access to Document

10.1016/0006-8993(84)90495-5

Cite this

@article{305009bf7bcf4b3892b8c6aa79af68b2,

title = "Acute haloperidol increases impulse activity of brain noradrenergic neurons",

abstract = "Haloperidol (0.5 mg/kg, i.p.) increased impulse activity of every noradrenergic locus coeruleus neuron tested in chloral hydrate anesthetized rats. Mean discharge rate increased from 1.4 ± 0.2 Hz before to 2.7 ± 0.4 Hz at 45 min after injection, with significantly increased activity occurring by 15 min post-drug. Elevated activity was apparent for at least 2 h following haloperidol. These results reveal that haloperidol has profound effects on brain noradrenergic neurons, indicating a possible site of action for effects of this neuroleptic agent.",

keywords = "haloperidol, locus coeruleus, neuroleptics, norepinephrine, pharmacogenic depression, unit recordings",

author = "Dinan, {Timothy G.} and Gary Aston-Jones",

note = "Funding Information: We thank Robert Shaver for assistance in these studies. This work was supported by N1NCDS Grant NS19360, BRSG Grant S07RR7149-09, and SUNY Research Foundation Grant 0140-03.",

year = "1984",

month = jul,

day = "30",

doi = "10.1016/0006-8993(84)90495-5",

language = "English (US)",

volume = "307",

pages = "359--362",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "1-2",

}

TY - JOUR

T1 - Acute haloperidol increases impulse activity of brain noradrenergic neurons

AU - Dinan, Timothy G.

AU - Aston-Jones, Gary

N1 - Funding Information: We thank Robert Shaver for assistance in these studies. This work was supported by N1NCDS Grant NS19360, BRSG Grant S07RR7149-09, and SUNY Research Foundation Grant 0140-03.

PY - 1984/7/30

Y1 - 1984/7/30

N2 - Haloperidol (0.5 mg/kg, i.p.) increased impulse activity of every noradrenergic locus coeruleus neuron tested in chloral hydrate anesthetized rats. Mean discharge rate increased from 1.4 ± 0.2 Hz before to 2.7 ± 0.4 Hz at 45 min after injection, with significantly increased activity occurring by 15 min post-drug. Elevated activity was apparent for at least 2 h following haloperidol. These results reveal that haloperidol has profound effects on brain noradrenergic neurons, indicating a possible site of action for effects of this neuroleptic agent.

AB - Haloperidol (0.5 mg/kg, i.p.) increased impulse activity of every noradrenergic locus coeruleus neuron tested in chloral hydrate anesthetized rats. Mean discharge rate increased from 1.4 ± 0.2 Hz before to 2.7 ± 0.4 Hz at 45 min after injection, with significantly increased activity occurring by 15 min post-drug. Elevated activity was apparent for at least 2 h following haloperidol. These results reveal that haloperidol has profound effects on brain noradrenergic neurons, indicating a possible site of action for effects of this neuroleptic agent.

KW - haloperidol

KW - locus coeruleus

KW - neuroleptics

KW - norepinephrine

KW - pharmacogenic depression

KW - unit recordings

UR - http://www.scopus.com/inward/record.url?scp=0021252159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021252159&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(84)90495-5

DO - 10.1016/0006-8993(84)90495-5

M3 - Article

C2 - 6147177

AN - SCOPUS:0021252159

SN - 0006-8993

VL - 307

SP - 359

EP - 362

JO - Brain research

JF - Brain research

IS - 1-2

ER -

Acute haloperidol increases impulse activity of brain noradrenergic neurons

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this