Acute haloperidol increases impulse activity of brain noradrenergic neurons

Timothy G. Dinan, Gary Aston-Jones

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Haloperidol (0.5 mg/kg, i.p.) increased impulse activity of every noradrenergic locus coeruleus neuron tested in chloral hydrate anesthetized rats. Mean discharge rate increased from 1.4 ± 0.2 Hz before to 2.7 ± 0.4 Hz at 45 min after injection, with significantly increased activity occurring by 15 min post-drug. Elevated activity was apparent for at least 2 h following haloperidol. These results reveal that haloperidol has profound effects on brain noradrenergic neurons, indicating a possible site of action for effects of this neuroleptic agent.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalBrain research
Volume307
Issue number1-2
DOIs
StatePublished - Jul 30 1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • haloperidol
  • locus coeruleus
  • neuroleptics
  • norepinephrine
  • pharmacogenic depression
  • unit recordings

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