Acute myelogenous leukemia without maturation with a retinoic alpha-receptor deletion: A case report

Christopher Trosclair; Maressa Pollen; Gerald Capraro; James Cotelingam; Rodney E. Shackelford

doi:10.1159/000365002

Acute myelogenous leukemia without maturation with a retinoic alpha-receptor deletion: A case report

Christopher Trosclair, Maressa Pollen, Gerald Capraro, James Cotelingam, Rodney E. Shackelford

Research output: Contribution to journal › Article › peer-review

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Abstract

Acute promyelocytic leukemia (APL) is characterized by a t(15;17) which fuses the 17q retinoic acid alpha-receptor sequence to the 15q PML gene sequence. The resulting fusion product plays a role in the development and maintenance of APL, and is very rarely found in other acute myeloid leukemia (AML) subtypes. Rare complex APL genomic rearrangements have retinoic acid alpha-receptor sequence deletions. Here we report a retinoic acid alpha-receptor sequence deletion in a case of AML without differentiation. To our knowledge, this is the first example of a retinoic acid alpha-receptor sequence deletion in this AML subtype.

Original language	English (US)
Pages (from-to)	407-409
Number of pages	3
Journal	Case Reports in Oncology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1159/000365002
State	Published - Mar 6 2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology

Keywords

Acute myelogenous leukemia without maturation
Acute promyelocytic leukemia
AML-M1
AML-M3
Deletion
PML/RAR?
t(15;17)(q22;q21)

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10.1159/000365002

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abstract = "Acute promyelocytic leukemia (APL) is characterized by a t(15;17) which fuses the 17q retinoic acid alpha-receptor sequence to the 15q PML gene sequence. The resulting fusion product plays a role in the development and maintenance of APL, and is very rarely found in other acute myeloid leukemia (AML) subtypes. Rare complex APL genomic rearrangements have retinoic acid alpha-receptor sequence deletions. Here we report a retinoic acid alpha-receptor sequence deletion in a case of AML without differentiation. To our knowledge, this is the first example of a retinoic acid alpha-receptor sequence deletion in this AML subtype.",

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AU - Trosclair, Christopher

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AU - Capraro, Gerald

AU - Cotelingam, James

AU - Shackelford, Rodney E.

PY - 2014/3/6

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Acute myelogenous leukemia without maturation with a retinoic alpha-receptor deletion: A case report

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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