@article{96d1b6288e79424b94000b93a518059e,
title = "Acute respiratory distress syndrome and COVID-19 in a child with systemic lupus erythematosus",
abstract = "We report a case of COVID-19 in a pediatric patient with systemic lupus erythematosus (SLE), who presented with respiratory distress marked by increased work of breathing and low oxygen saturation. Lab tests confirmed COVID-19, and showed lymphocytopenia and elevated markers of inflammation and coagulopathy. Chest X-ray showed bilateral mid-lung opacities, and the patient required intubation early in his disease course. Imaging and clinical findings were consistent with acute respiratory distress syndrome (ARDS) with inflammation. The patient was treated with different combinations of antivirals (hydroxychloroquine and remdesivir), cytokine inhibitors (anakinra and tocilizumab), glucocorticoids (hydrocortisone and methylprednisolone), and an anticoagulant (enoxaparin). Inflammatory markers decreased before clinical improvement in lung aeration. This case highlights the potential for pediatric patients with SLE to present with COVID-19 similar to the clinical presentation described in adults.",
keywords = "ARDS, COVID-19, Systemic lupus erythematosus, pediatric",
author = "Simone Sukhdeo and Emily Negroponte and Hariprem Rajasekhar and Sunanda Gaur and Horton, {Daniel B.} and Amisha Malhotra and Moorthy, {L. Nandini}",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Research reported in this publication was supported (in part) by the New Jersey Alliance for Clinical and Translational Science and the National Center for Advancing Translational Sciences (NCATS), a component of the National Institute of Health (NIH) under award number UL1TR003017. Funding Information: We would like to thank Jovanna Madray, DO, for her contribution to this work. The manuscript was seen and approved by all authors. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Research reported in this publication was supported (in part) by the New Jersey Alliance for Clinical and Translational Science and the National Center for Advancing Translational Sciences (NCATS), a component of the National Institute of Health (NIH) under award number UL1TR003017. Publisher Copyright: {\textcopyright} The Author(s) 2021.",
year = "2021",
month = apr,
doi = "10.1177/0961203321989791",
language = "English (US)",
volume = "30",
pages = "836--839",
journal = "Lupus",
issn = "0961-2033",
publisher = "SAGE Publications Ltd",
number = "5",
}