Adaptation of liquid handling robotics for high throughput customizable raft-polymerization

Matthew Tamasi, Shashank Kosuri, Rahul Upadhya, Adam Gormley

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Reversible addition-fragmentation chain transfer (RAFT) polymerization enables precise control over molecular weight and polydispersity and allows for investigation of complex polymer architectures with bioactive functionality (Yeow, Chapman et al. 2017). Traditionally, this oxygen-intolerant polymer chemistry is done in batch processes that are technically challenging and time consuming to complete. Recently, we have shown that oxygen-tolerant porphyrin-catalyzed photoinduced electron transfer RAFT (PET-RAFT) polymerization enables combinatorial preparation of bioactive polymers in 96 or 384 well plates (Gormley, Yeow et al. 2018). 1 To further expand on this unique capability and make polymer chemistry accessible to the non-expert, we have programmed a Hamilton Microlab STARlet liquid handling robot to perform high throughput polymer chemistry and bioconjugation based on a user-friendly graphical user interface (GUI). This automation allows for the reliable and simple creation of customizable polymers for a variety of biological applications.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Externally publishedYes
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Robotics
Polymerization
Polymers
Throughput
Liquids
Oxygen
Automation
Porphyrins
Polydispersity
Graphical user interfaces
Molecular Weight
Molecular weight
Robots
Electrons

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Tamasi, M., Kosuri, S., Upadhya, R., & Gormley, A. (2019). Adaptation of liquid handling robotics for high throughput customizable raft-polymerization. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.
Tamasi, Matthew ; Kosuri, Shashank ; Upadhya, Rahul ; Gormley, Adam. / Adaptation of liquid handling robotics for high throughput customizable raft-polymerization. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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Tamasi, M, Kosuri, S, Upadhya, R & Gormley, A 2019, Adaptation of liquid handling robotics for high throughput customizable raft-polymerization. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.

Adaptation of liquid handling robotics for high throughput customizable raft-polymerization. / Tamasi, Matthew; Kosuri, Shashank; Upadhya, Rahul; Gormley, Adam.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Tamasi M, Kosuri S, Upadhya R, Gormley A. Adaptation of liquid handling robotics for high throughput customizable raft-polymerization. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).