Adaptive Lumpectomy Boost Planning Can Reduce Normal Tissue Exposure in Patients Receiving Hypofractionated Whole Breast Irradiation

Mutlay Sayan; Zeinab Abou Yehia; Imraan Jan; Apar Gupta; Irina Vergalasova; Marc Reviello; Shicha Kumar; Bruce Haffty; Nisha Ohri

doi:10.21873/anticanres.15456

Adaptive Lumpectomy Boost Planning Can Reduce Normal Tissue Exposure in Patients Receiving Hypofractionated Whole Breast Irradiation

Mutlay Sayan, Zeinab Abou Yehia, Imraan Jan, Apar Gupta, Irina Vergalasova, Marc Reviello, Shicha Kumar, Bruce Haffty, Nisha Ohri

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background/Aim: To evaluate the change in lumpectomy cavity (LPC) volume during hypofractionated radiation (Hypo-RT) and assess the dosimetric benefits of adaptive boost planning on normal tissue exposure in breast cancer patients. Patients and Methods: Two separate computed tomography (CT) simulation scans were obtained. The first (CT1) was used to plan whole breast irradiation, and the second (CT2) was used to plan LPC boost. LPC boost treatment planning was performed on both CT1 and CT2. Results: Mean LPC volume was significantly smaller on CT2 compared to CT1. LPC boost plan comparison showed significant reductions from CT1 to CT2 in mean heart dose and mean lung dose. Mean volume of tissue receiving 95% of the prescribed boost dose (V95) was lower on CT2 (p=0.001), as was V80 (p<0.001) and V50 (p<0.001). Conclusion: LPC volume can change significantly during Hypo-RT. Adaptive LPC boost planning can be considered to reduce normal tissue exposure.

Original language	English (US)
Pages (from-to)	53-57
Number of pages	5
Journal	Anticancer Research
Volume	42
Issue number	1
DOIs	https://doi.org/10.21873/anticanres.15456
State	Published - Jan 2022

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Keywords

Breast
Carcinoma
Hypofractionation
Mastectomy
Radiotherapy
Segmental

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title = "Adaptive Lumpectomy Boost Planning Can Reduce Normal Tissue Exposure in Patients Receiving Hypofractionated Whole Breast Irradiation",

abstract = "Background/Aim: To evaluate the change in lumpectomy cavity (LPC) volume during hypofractionated radiation (Hypo-RT) and assess the dosimetric benefits of adaptive boost planning on normal tissue exposure in breast cancer patients. Patients and Methods: Two separate computed tomography (CT) simulation scans were obtained. The first (CT1) was used to plan whole breast irradiation, and the second (CT2) was used to plan LPC boost. LPC boost treatment planning was performed on both CT1 and CT2. Results: Mean LPC volume was significantly smaller on CT2 compared to CT1. LPC boost plan comparison showed significant reductions from CT1 to CT2 in mean heart dose and mean lung dose. Mean volume of tissue receiving 95% of the prescribed boost dose (V95) was lower on CT2 (p=0.001), as was V80 (p<0.001) and V50 (p<0.001). Conclusion: LPC volume can change significantly during Hypo-RT. Adaptive LPC boost planning can be considered to reduce normal tissue exposure.",

keywords = "Breast, Carcinoma, Hypofractionation, Mastectomy, Radiotherapy, Segmental",

author = "Mutlay Sayan and Yehia, {Zeinab Abou} and Imraan Jan and Apar Gupta and Irina Vergalasova and Marc Reviello and Shicha Kumar and Bruce Haffty and Nisha Ohri",

year = "2022",

month = jan,

doi = "10.21873/anticanres.15456",

language = "English (US)",

volume = "42",

pages = "53--57",

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publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Adaptive Lumpectomy Boost Planning Can Reduce Normal Tissue Exposure in Patients Receiving Hypofractionated Whole Breast Irradiation

AU - Sayan, Mutlay

AU - Yehia, Zeinab Abou

AU - Jan, Imraan

AU - Gupta, Apar

AU - Vergalasova, Irina

AU - Reviello, Marc

AU - Kumar, Shicha

AU - Haffty, Bruce

AU - Ohri, Nisha

PY - 2022/1

Y1 - 2022/1

N2 - Background/Aim: To evaluate the change in lumpectomy cavity (LPC) volume during hypofractionated radiation (Hypo-RT) and assess the dosimetric benefits of adaptive boost planning on normal tissue exposure in breast cancer patients. Patients and Methods: Two separate computed tomography (CT) simulation scans were obtained. The first (CT1) was used to plan whole breast irradiation, and the second (CT2) was used to plan LPC boost. LPC boost treatment planning was performed on both CT1 and CT2. Results: Mean LPC volume was significantly smaller on CT2 compared to CT1. LPC boost plan comparison showed significant reductions from CT1 to CT2 in mean heart dose and mean lung dose. Mean volume of tissue receiving 95% of the prescribed boost dose (V95) was lower on CT2 (p=0.001), as was V80 (p<0.001) and V50 (p<0.001). Conclusion: LPC volume can change significantly during Hypo-RT. Adaptive LPC boost planning can be considered to reduce normal tissue exposure.

AB - Background/Aim: To evaluate the change in lumpectomy cavity (LPC) volume during hypofractionated radiation (Hypo-RT) and assess the dosimetric benefits of adaptive boost planning on normal tissue exposure in breast cancer patients. Patients and Methods: Two separate computed tomography (CT) simulation scans were obtained. The first (CT1) was used to plan whole breast irradiation, and the second (CT2) was used to plan LPC boost. LPC boost treatment planning was performed on both CT1 and CT2. Results: Mean LPC volume was significantly smaller on CT2 compared to CT1. LPC boost plan comparison showed significant reductions from CT1 to CT2 in mean heart dose and mean lung dose. Mean volume of tissue receiving 95% of the prescribed boost dose (V95) was lower on CT2 (p=0.001), as was V80 (p<0.001) and V50 (p<0.001). Conclusion: LPC volume can change significantly during Hypo-RT. Adaptive LPC boost planning can be considered to reduce normal tissue exposure.

KW - Breast

KW - Carcinoma

KW - Hypofractionation

KW - Mastectomy

KW - Radiotherapy

KW - Segmental

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Adaptive Lumpectomy Boost Planning Can Reduce Normal Tissue Exposure in Patients Receiving Hypofractionated Whole Breast Irradiation

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