Adaptive Lumpectomy Boost Planning Can Reduce Normal Tissue Exposure in Patients Receiving Hypofractionated Whole Breast Irradiation

Mutlay Sayan, Zeinab Abou Yehia, Imraan Jan, Apar Gupta, Irina Vergalasova, Marc Reviello, Shicha Kumar, Bruce Haffty, Nisha Ohri

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: To evaluate the change in lumpectomy cavity (LPC) volume during hypofractionated radiation (Hypo-RT) and assess the dosimetric benefits of adaptive boost planning on normal tissue exposure in breast cancer patients. Patients and Methods: Two separate computed tomography (CT) simulation scans were obtained. The first (CT1) was used to plan whole breast irradiation, and the second (CT2) was used to plan LPC boost. LPC boost treatment planning was performed on both CT1 and CT2. Results: Mean LPC volume was significantly smaller on CT2 compared to CT1. LPC boost plan comparison showed significant reductions from CT1 to CT2 in mean heart dose and mean lung dose. Mean volume of tissue receiving 95% of the prescribed boost dose (V95) was lower on CT2 (p=0.001), as was V80 (p<0.001) and V50 (p<0.001). Conclusion: LPC volume can change significantly during Hypo-RT. Adaptive LPC boost planning can be considered to reduce normal tissue exposure.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalAnticancer Research
Volume42
Issue number1
DOIs
StatePublished - Jan 2022

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • Breast
  • Carcinoma
  • Hypofractionation
  • Mastectomy
  • Radiotherapy
  • Segmental

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