Adenosine as a neuromodulator in neurological diseases

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Abstract

Adenosine is a modulator of brain function uniquely positioned to integrate excitatory and inhibitory neurotransmission. The past few years brought a wealth of new data fostering our understanding of how the adenosine system is involved in the pathogenesis of neurological diseases. Thus, dysregulation of the adenosine system is implicated in epileptogenesis and cell therapies have been developed to locally augment adenosine in an approach to prevent seizures. While activation of inhibitory adenosine A1 receptors is beneficial in epilepsy, chronic pain and cerebral ischemia, inhibition of facilitatory A2A receptors has profound neuroprotective effects, which are currently exploited in clinical trials in Parkinson's disease. A new era of adenosine-based therapies has begun, with the prospect to cover a wide range of neurological diseases.

Original languageEnglish (US)
Pages (from-to)2-7
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume8
Issue number1
DOIs
StatePublished - Feb 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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