Adenoviral Infections in Pediatric Liver Transplant Recipients

Baburao Koneru, Ronald Jaffe, Carlos O. Esquivel, Rainer Kunz, Satuoro Todo, Shunzaburo Iwatsuki, Thomas E. Starzl

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Over a 51/2-year period, 22 of 262 children receiving liver transplants developed adenoviral infections. Five had adenoviral hepatitis in the allograft, caused by serotype 5. All five were treated for rejection, either just before or at the time of infection. Liver biopsy specimens had characteristic histological appearance, and diagnosis of adenoviral infection was confirmed with monoclonal antiadenoviral antibodies, electron microscopy, and by culture of liver tissue. In the remaining 17 patients, adenovirus was isolated from urine, stool, throat secretions, and/or blood samples, but none had any detectable visceral infection. Serotypes 1 and 2 predominated, similar to children not receiving transplants during the same time period. Three of the patients with hepatitis are alive and well; two died of liver failure. Adenoviral hepatitis did not recur in the second allograft of a patient who underwent retransplantation for combined rejection and adenoviral hepatitis, and appears, therefore, not to be a contraindication to retransplantation when liver failure ensues.

Original languageEnglish (US)
Pages (from-to)489-492
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Volume258
Issue number4
DOIs
StatePublished - Jul 24 1987

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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