Adherence to the dietary guidelines for Americans and endometrial cancer risk

Urmila Chandran, Elisa V. Bandera, Melony G. Williams-King, Camelia Sima, Sharon Bayuga, Katherine Pulick, Homer Wilcox, Ann G. Zauber, Sara H. Olson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The Healthy Eating Index (HEI) was developed by the US Department of Agriculture with the goal of quantifying adherence to the Dietary Guidelines for Americans. The purpose of this study was to evaluate the impact of the HEI-2005 score and each of its components on endometrial cancer risk in a population-based case-control study in New Jersey. A total of 424 cases and 398 controls completed a Food Frequency Questionnaire, which was used to derive the HEI-2005 score. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression while adjusting for potential covariates, which included all major endometrial cancer risk factors. The adjusted OR for women in the highest quartile when compared to the lowest quartile was 0.83 (95% CI: 0.52-1.34). For the meat and beans component comprising meat, eggs, poultry, fish, and beans, the OR was 0.70 (95% CI: 0.45-1.11; p for trend: 0.07), with little evidence of an association with any of the individual foods. There was no indication of an association for any of the other components of the HEI or of effect modification by body mass index. This study suggested limited value for the HEI-2005 in predicting endometrial cancer risk.

Original languageEnglish (US)
Pages (from-to)1895-1904
Number of pages10
JournalCancer Causes and Control
Issue number11
StatePublished - Nov 2010

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


  • Beans
  • Dairy
  • Diet
  • Endometrial cancer
  • Food
  • Fruit
  • Grain
  • Healthy Eating Index
  • Meat
  • Oils
  • Saturated fat
  • Vegetables
  • Whole grain


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