Advanced technologies for the preservation of mammalian biospecimens

Haishui Huang, Xiaoming He, Martin L. Yarmush

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


The three classical core technologies for the preservation of live mammalian biospecimens—slow freezing, vitrification and hypothermic storage—limit the biomedical applications of biospecimens. In this Review, we summarize the principles and procedures of these three technologies, highlight how their limitations are being addressed via the combination of microfabrication and nanofabrication, materials science and thermal-fluid engineering and discuss the remaining challenges.

Original languageEnglish (US)
Pages (from-to)793-804
Number of pages12
JournalNature biomedical engineering
Issue number8
StatePublished - Aug 2021

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications


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