Advances in cancer tissue microarray technology: Towards improved understanding and diagnostics

Wenjin Chen, David J. Foran

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Over the past few years, tissue microarray (TMA) technology has been established as a standard method for assessing the expression of proteins or genes across large sets of tissue specimens. It is being adopted increasingly among leading research institutions around the world and utilized in cancer research in parallel with the cDNA microarray technology. This article summarizes various aspects of cancer understanding and diagnostics in which TMA has had great impact. Although tremendous advances continue to be made to facilitate imaging and archiving of TMA specimens, automatic evaluation and quantitative analysis of TMA still remains an important challenge for modern investigators.

Original languageEnglish (US)
Pages (from-to)74-81
Number of pages8
JournalAnalytica Chimica Acta
Volume564
Issue number1
DOIs
StatePublished - Mar 30 2006

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

Keywords

  • Automatic tissue analysis
  • Molecular marker quantification
  • Molecular profiling
  • Tissue microarray

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