Abstract
Heterologous biosynthesis has been long pursued as a viable approach for high efficiency production of natural products with various industrial values. Conventional methods for heterologous biosynthesis use the mono-culture of an engineered microbe for accommodating the whole target biosynthetic pathway to produce the desired product. The emergence of modular co-culture engineering, which divides the pathway between multiple co-culture strains, presents a new perspective to conduct heterologous biosynthesis and improve the bioproduction performance of natural products. This review highlights recent advances in utilizing the modular co-culture engineering approaches to address the challenges of plant and fungal natural product biosynthesis. Potential directions for future research in this promising field are also discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 27-34 |
| Number of pages | 8 |
| Journal | Biotechnology Letters |
| Volume | 41 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 15 2019 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Bioengineering
- Applied Microbiology and Biotechnology
Keywords
- Bioproduction improvement
- Heterologous biosynthesis
- Modular co-culture engineering
- Natural product
- Plants and fungus
Cite this
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Advances in heterologous biosynthesis of plant and fungal natural products by modular co-culture engineering. / Chen, Tingting; Zhou, Yiyao; Lu, Yinghua; Zhang, Haoran.
In: Biotechnology Letters, Vol. 41, No. 1, 15.01.2019, p. 27-34.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Advances in heterologous biosynthesis of plant and fungal natural products by modular co-culture engineering
AU - Chen, Tingting
AU - Zhou, Yiyao
AU - Lu, Yinghua
AU - Zhang, Haoran
PY - 2019/1/15
Y1 - 2019/1/15
N2 - Heterologous biosynthesis has been long pursued as a viable approach for high efficiency production of natural products with various industrial values. Conventional methods for heterologous biosynthesis use the mono-culture of an engineered microbe for accommodating the whole target biosynthetic pathway to produce the desired product. The emergence of modular co-culture engineering, which divides the pathway between multiple co-culture strains, presents a new perspective to conduct heterologous biosynthesis and improve the bioproduction performance of natural products. This review highlights recent advances in utilizing the modular co-culture engineering approaches to address the challenges of plant and fungal natural product biosynthesis. Potential directions for future research in this promising field are also discussed.
AB - Heterologous biosynthesis has been long pursued as a viable approach for high efficiency production of natural products with various industrial values. Conventional methods for heterologous biosynthesis use the mono-culture of an engineered microbe for accommodating the whole target biosynthetic pathway to produce the desired product. The emergence of modular co-culture engineering, which divides the pathway between multiple co-culture strains, presents a new perspective to conduct heterologous biosynthesis and improve the bioproduction performance of natural products. This review highlights recent advances in utilizing the modular co-culture engineering approaches to address the challenges of plant and fungal natural product biosynthesis. Potential directions for future research in this promising field are also discussed.
KW - Bioproduction improvement
KW - Heterologous biosynthesis
KW - Modular co-culture engineering
KW - Natural product
KW - Plants and fungus
UR - http://www.scopus.com/inward/record.url?scp=85056132791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056132791&partnerID=8YFLogxK
U2 - 10.1007/s10529-018-2619-z
DO - 10.1007/s10529-018-2619-z
M3 - Review article
C2 - 30382453
AN - SCOPUS:85056132791
VL - 41
SP - 27
EP - 34
JO - Biotechnology Letters
JF - Biotechnology Letters
SN - 0141-5492
IS - 1
ER -