Adverse effects of enalapril in the Studies of Left Ventricular Dysfunction (SOLVD)

John B. Kostis, Brent Shelton, Gilbert Gosselin, Claude Goulet, William B. Hood, Robert M. Kohn, Spencer H. Kubo, Eleanor Schron, Melvin B. Weiss, Park W. Willis, James B. Young, Jeffrey Probstfield

Research output: Contribution to journalArticlepeer-review

146 Scopus citations


In the Studies of Left Ventricular Dysfunction (LVD), enalapril or placebo was administered in a double-blind fashion to 6797 participants with ejection fraction ≤0.35. During 40 months' average follow-up, 28.1% of participants randomized to enalapril reported side effects compared with 16.0% in the placebo group (p < 0.0001). Enalapril use was associated with a higher rate of symptoms related to hypotension (14.8% vs 7.1%, p<0.0001), azotemia (3.8% vs 1.6%, p < 0.0001), cough (5.0% vs 2.0%, p < 0.0001), fatigue (5.8% vs 3.5%, p < 0.0001), hyperkalemia (1.2% vs 0.4%, p = 0.0002), and angioedema (0.4% vs 0.1%, p<0.05). Side effects resulted in discontinuation of blinded therapy in 15.2% of the enalapril group compared with 8.6% in the placebo group (p < 0.0001). Thus analapril is well tolerated by patients with LVD; however, hypotension, azotemia, cough, fatigue, and other side effects result in discontinuation of therapy in a significant minority of patients.

Original languageEnglish (US)
Pages (from-to)350-355
Number of pages6
JournalAmerican heart journal
Issue number2
StatePublished - 1996

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Adverse effects of enalapril in the Studies of Left Ventricular Dysfunction (SOLVD)'. Together they form a unique fingerprint.

Cite this