Affective illness and HLA frequencies: No compelling association

N. M. James, P. E. Smouse, B. J. Carroll, R. F. Haines

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


114 patients suffering from an endogenomorphic affective illness were typed for HLA antigens at the A and B loci, and the frequencies were compared with those of a control panel numbering 439 individuals. Using new analytical procedures, a large number of tests were conducted, but no convincing evidence for an association of HLA types with affective disorders was obtained. A reanalysis of the same data, where patients are classified according to Danish diagnostic criteria, yields a marginally significant association of the B locus alleles. The sample sizes for this latter analysis were small, the test criteria are undoubtedly inflated, and no compelling case can be made for a useful association.

Original languageEnglish (US)
Pages (from-to)208-216
Number of pages9
Issue number4
StatePublished - 1980
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry


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