Age-related differential sensitivity to MK-801-induced locomotion and stereotypy in C57BL/6 mice

Chunting Qi, Hong Zou, Ruizhong Zhang, Guoping Zhao, Meilei Jin, Lei Yu

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Psychomotor effects elicited by systemic administration of the noncompetitive NMDA (N-methyl-d-aspartate) receptor antagonist MK-801 (dizocilpine maleate) represent perturbation of glutamatergic pathways, providing an animal model for psychotic symptoms of schizophrenia. Hyperlocomotion and stereotypy are the two main psychomotor behaviors induced by MK-801. This study compared MK-801-induced hyperlocomotion and stereotypy in young (1-month old) and aged mice (12-month old), in order to determine how the aging process may influence these behaviors. The tested MK-801 doses ranged from 0.015 to 1 mg/kg. The data indicated that MK-801 impacted the aged mice more pronouncedly than the young mice, as both hyperlocomotion and stereotypy were increased significantly more in the aged mice relative to the young mice. These results suggest an age-related increase in MK-801 sensitivity in mice.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalEuropean Journal of Pharmacology
Volume580
Issue number1-2
DOIs
StatePublished - Feb 2 2008

All Science Journal Classification (ASJC) codes

  • Pharmacology

Keywords

  • Aging
  • Differential drug sensitivity
  • Dizocilpine maleate
  • Locomotion
  • Noncompetitive NMDA receptor antagonist
  • Stereotypy

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