Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions

Xiao Dong, Shixiang Sun, Lei Zhang, Seungsoo Kim, Zhidong Tu, Cristina Montagna, Alexander Y. Maslov, Yousin Suh, Tao Wang, Judith Campisi, Jan Vijg

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age-related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome-wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging.

Original languageEnglish (US)
Article numbere13357
JournalAging cell
Issue number6
StatePublished - Jun 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Aging
  • Cell Biology


  • aging
  • gene expression
  • telomere shortening


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