Aged citrus peel (chenpi) extract reduces lipogenesis in differentiating 3T3-L1 adipocytes

Jingjing Guo, Yong Cao, Chi-Tang Ho, Shengkan Jin, Qingrong Huang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aged citrus peel (chenpi) is made from the dry peel of the fruit of Citrus reticulate Blanco after aging process. It has long been used as a food ingredient, a dietary supplement, and for medicinal purpose. Compared to fresh citrus peel extract, chenpi extract contains more 5-demethylated polymethoxyflavones (5-OH PMFs). To investigate a potential direct role of chenpi extract on adipose tissue, we examined the effect of chenpi extract on differentiating 3T3-L1 cells. We showed that two types of chenpi extract varying in 5-OH PMF contents consistently reduces intracellular lipid accumulation without significantly affecting cell viability and proliferation. The reduction in lipid accumulation is correlated with AMP-activated protein kinase (AMPK) activation and down-regulation of adipogenic transcription factors as well as lipogenic genes. The results indicate that chenpi extract may directly affect lipogenesis in adipose tissue and the content of 5-OH PMFs likely affects the anti-lipogenic activity of chenpi extract.

Original languageEnglish (US)
Pages (from-to)297-303
Number of pages7
JournalJournal of Functional Foods
Volume34
DOIs
StatePublished - Jul 1 2017

Fingerprint

citrus peels
Lipogenesis
Citrus
lipogenesis
adipocytes
Adipocytes
extracts
adipose tissue
Adipose Tissue
3T3-L1 Cells
Lipids
AMP-activated protein kinase
Citrus reticulata
AMP-Activated Protein Kinases
fruit peels
lipids
Dietary Supplements
chenpi
cell viability
dietary supplements

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Keywords

  • 5-Demethylated polymethoxyflavones
  • AMPK
  • Adipogenesis
  • Chenpi
  • Lipogenesis
  • Obesity

Cite this

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title = "Aged citrus peel (chenpi) extract reduces lipogenesis in differentiating 3T3-L1 adipocytes",
abstract = "Aged citrus peel (chenpi) is made from the dry peel of the fruit of Citrus reticulate Blanco after aging process. It has long been used as a food ingredient, a dietary supplement, and for medicinal purpose. Compared to fresh citrus peel extract, chenpi extract contains more 5-demethylated polymethoxyflavones (5-OH PMFs). To investigate a potential direct role of chenpi extract on adipose tissue, we examined the effect of chenpi extract on differentiating 3T3-L1 cells. We showed that two types of chenpi extract varying in 5-OH PMF contents consistently reduces intracellular lipid accumulation without significantly affecting cell viability and proliferation. The reduction in lipid accumulation is correlated with AMP-activated protein kinase (AMPK) activation and down-regulation of adipogenic transcription factors as well as lipogenic genes. The results indicate that chenpi extract may directly affect lipogenesis in adipose tissue and the content of 5-OH PMFs likely affects the anti-lipogenic activity of chenpi extract.",
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Aged citrus peel (chenpi) extract reduces lipogenesis in differentiating 3T3-L1 adipocytes. / Guo, Jingjing; Cao, Yong; Ho, Chi-Tang; Jin, Shengkan; Huang, Qingrong.

In: Journal of Functional Foods, Vol. 34, 01.07.2017, p. 297-303.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Guo, Jingjing

AU - Cao, Yong

AU - Ho, Chi-Tang

AU - Jin, Shengkan

AU - Huang, Qingrong

PY - 2017/7/1

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AB - Aged citrus peel (chenpi) is made from the dry peel of the fruit of Citrus reticulate Blanco after aging process. It has long been used as a food ingredient, a dietary supplement, and for medicinal purpose. Compared to fresh citrus peel extract, chenpi extract contains more 5-demethylated polymethoxyflavones (5-OH PMFs). To investigate a potential direct role of chenpi extract on adipose tissue, we examined the effect of chenpi extract on differentiating 3T3-L1 cells. We showed that two types of chenpi extract varying in 5-OH PMF contents consistently reduces intracellular lipid accumulation without significantly affecting cell viability and proliferation. The reduction in lipid accumulation is correlated with AMP-activated protein kinase (AMPK) activation and down-regulation of adipogenic transcription factors as well as lipogenic genes. The results indicate that chenpi extract may directly affect lipogenesis in adipose tissue and the content of 5-OH PMFs likely affects the anti-lipogenic activity of chenpi extract.

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