Agents of Last Resort: Polymyxin Resistance

Keith S. Kaye; Jason M. Pogue; Thien B. Tran; Roger L. Nation; Jian Li

doi:10.1016/j.idc.2016.02.005

Agents of Last Resort: Polymyxin Resistance

Keith S. Kaye, Jason M. Pogue, Thien B. Tran, Roger L. Nation, Jian Li

Research output: Contribution to journal › Review article › peer-review

155 Scopus citations

Abstract

Polymyxin resistance is a major public health threat, as the polymyxins represent “last-line” therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.

Original language	English (US)
Pages (from-to)	391-414
Number of pages	24
Journal	Infectious Disease Clinics of North America
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/j.idc.2016.02.005
State	Published - Jun 1 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

Keywords

Colistin
Gram-negative
Polymyxin B
Polymyxins
Resistance

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10.1016/j.idc.2016.02.005

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title = "Agents of Last Resort: Polymyxin Resistance",

abstract = "Polymyxin resistance is a major public health threat, as the polymyxins represent “last-line” therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.",

keywords = "Colistin, Gram-negative, Polymyxin B, Polymyxins, Resistance",

author = "Kaye, {Keith S.} and Pogue, {Jason M.} and Tran, {Thien B.} and Nation, {Roger L.} and Jian Li",

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year = "2016",

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doi = "10.1016/j.idc.2016.02.005",

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T2 - Polymyxin Resistance

AU - Kaye, Keith S.

AU - Pogue, Jason M.

AU - Tran, Thien B.

AU - Nation, Roger L.

AU - Li, Jian

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Polymyxin resistance is a major public health threat, as the polymyxins represent “last-line” therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.

AB - Polymyxin resistance is a major public health threat, as the polymyxins represent “last-line” therapeutics for Gram-negative pathogens resistant to essentially all other antibiotics. Improved understanding of mechanisms of, and risk factors for, polymyxin resistance, as well as infection prevention and stewardship strategies, together with optimization of dosing of polymyxins including in combination regimens, can help to limit the emergence and dissemination of polymyxin resistance.

KW - Colistin

KW - Gram-negative

KW - Polymyxin B

KW - Polymyxins

KW - Resistance

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DO - 10.1016/j.idc.2016.02.005

M3 - Review article

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AN - SCOPUS:84991383747

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JO - Infectious Disease Clinics of North America

JF - Infectious Disease Clinics of North America

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ER -

Agents of Last Resort: Polymyxin Resistance

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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