Aggregation of acridine orange: Crystal structure of acridine orange tetrachlorozincate 2C17H19N3·2HCl·ZnCl2·CH3COOH

S. K. Obendorf, Jenny Pickworth Glusker, Paul R. Hansen, Helen M. Berman, H. L. Carrell

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The crystal structure of the biological stain, "acridine orange," has been determined. This compound, when crystallized from ethanol, is shown to be a zinc chloride double salt of acridine orange, containing, in addition, acetic acid of crystallization. These additional components are residuals from the method of preparation of acridine orange. This complex, 2 acridine orange·2HCl·ZnCl2·CH3COOH, (2C17H19N3·2HCl·ZnCl2·CH3COOH) crystallizes in the monoclinic space group P21, a = 9.965 (2), b = 21.507 (6), c = 9.645 (2) Å, β = 113.98° (2), V = 1888.7 (8) Å3, FW = 800.0, Z = 2, Dx = 1.41 g·cm-3, Dobs = 1.43 (9) g·cm-3. Three-dimensional diffraction data were collected with CuKα radiation, and the structure refined to R = 0.065 for 1885 observed reflections. In the crystal structure hydrogen bonds are formed.

Original languageEnglish (US)
Pages (from-to)29-44
Number of pages16
JournalBioinorganic Chemistry
Issue number1
StatePublished - 1976
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry


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