Aging: Fewer Obstacles to DNA Replication?

Andreas S. Ivessa

doi:10.1016/j.trecan.2017.04.003

Aging: Fewer Obstacles to DNA Replication?

Andreas S. Ivessa

New Jersey Medical School (NJMS), Cell Biology & Molecular Medicine

Research output: Contribution to journal › Short survey › peer-review

Abstract

Many cancers are initiated by loss-of-heterozygosity (LOH) events that lead to the replacement of single, functional tumor suppressor genes by the mutant alleles. The underlying mechanisms, of why LOH rates increase with age, are not well understood. We discuss the possible involvement of difficult-to-replicate (fragile) chromosomal sites in this process.

Original language	English (US)
Pages (from-to)	387-390
Number of pages	4
Journal	Trends in Cancer
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/j.trecan.2017.04.003
State	Published - Jun 2017

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

Keywords

DNA breakage
DNA replication
aging
fragile sites
loss-of-heterozygosity
nuclear genomic instability

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10.1016/j.trecan.2017.04.003

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@article{835abc2281b442c39bcafae0350b78ef,

title = "Aging: Fewer Obstacles to DNA Replication?",

abstract = "Many cancers are initiated by loss-of-heterozygosity (LOH) events that lead to the replacement of single, functional tumor suppressor genes by the mutant alleles. The underlying mechanisms, of why LOH rates increase with age, are not well understood. We discuss the possible involvement of difficult-to-replicate (fragile) chromosomal sites in this process.",

keywords = "DNA breakage, DNA replication, aging, fragile sites, loss-of-heterozygosity, nuclear genomic instability",

author = "Ivessa, {Andreas S.}",

note = "Funding Information: This work was supported by NIH grant R21AG047423. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = jun,

doi = "10.1016/j.trecan.2017.04.003",

language = "English (US)",

volume = "3",

pages = "387--390",

journal = "Trends in Cancer",

issn = "2405-8033",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - Aging

T2 - Fewer Obstacles to DNA Replication?

AU - Ivessa, Andreas S.

PY - 2017/6

Y1 - 2017/6

N2 - Many cancers are initiated by loss-of-heterozygosity (LOH) events that lead to the replacement of single, functional tumor suppressor genes by the mutant alleles. The underlying mechanisms, of why LOH rates increase with age, are not well understood. We discuss the possible involvement of difficult-to-replicate (fragile) chromosomal sites in this process.

AB - Many cancers are initiated by loss-of-heterozygosity (LOH) events that lead to the replacement of single, functional tumor suppressor genes by the mutant alleles. The underlying mechanisms, of why LOH rates increase with age, are not well understood. We discuss the possible involvement of difficult-to-replicate (fragile) chromosomal sites in this process.

KW - DNA breakage

KW - DNA replication

KW - aging

KW - fragile sites

KW - loss-of-heterozygosity

KW - nuclear genomic instability

UR - http://www.scopus.com/inward/record.url?scp=85018459947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018459947&partnerID=8YFLogxK

U2 - 10.1016/j.trecan.2017.04.003

DO - 10.1016/j.trecan.2017.04.003

M3 - Short survey

C2 - 28718415

AN - SCOPUS:85018459947

SN - 2405-8033

VL - 3

SP - 387

EP - 390

JO - Trends in Cancer

JF - Trends in Cancer

IS - 6

ER -

Aging: Fewer Obstacles to DNA Replication?

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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