Aging: Fewer Obstacles to DNA Replication?

Research output: Contribution to journalShort surveypeer-review

Abstract

Many cancers are initiated by loss-of-heterozygosity (LOH) events that lead to the replacement of single, functional tumor suppressor genes by the mutant alleles. The underlying mechanisms, of why LOH rates increase with age, are not well understood. We discuss the possible involvement of difficult-to-replicate (fragile) chromosomal sites in this process.

Original languageEnglish (US)
Pages (from-to)387-390
Number of pages4
JournalTrends in Cancer
Volume3
Issue number6
DOIs
StatePublished - Jun 2017

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • DNA breakage
  • DNA replication
  • aging
  • fragile sites
  • loss-of-heterozygosity
  • nuclear genomic instability

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