Aging, neurodegenerative disease, and traumatic brain injury: The role of neuroimaging

Carrie Esopenko, Brian Levine

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Traumatic brain injury (TBI) is a highly prevalent condition with significant effects on cognition and behavior. While the acute and sub-acute effects of TBI recover over time, relatively little is known about the long-term effects of TBI in relation to neurodegenerative disease. This issue has recently garnered a great deal of attention due to publicity surrounding chronic traumatic encephalopathy (CTE) in professional athletes, although CTE is but one of several neurodegenerative disorders associated with a history of TBI. Here, we review the literative on neurodegenerative disorders linked to remote TBI. We also review the evidence for neuroimaging changes associated with unhealthy brain aging in the context of remote TBI. We conclude that neuroimaging biomarkers have significant potential to increase understanding of the mechanisms of unhealthy brain aging and neurodegeneration following TBI, with potential for identifying those at risk for unhealthy brain aging prior to the clinical manifestation of neurodegenerative disease.

Original languageEnglish (US)
Pages (from-to)209-220
Number of pages12
JournalJournal of neurotrauma
Issue number4
StatePublished - Feb 15 2015

All Science Journal Classification (ASJC) codes

  • Clinical Neurology


  • Alzheimer's disease
  • aging
  • chronic traumatic encephalopathy
  • neurodegenerative disease
  • remote traumatic brain injury


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