Agr-related sequences in Staphylococcus lugdunensis

François Vandenesch; Steven J. Projan; Barry Kreiswirth; Jerome Etienne; Richard P. Novick

doi:10.1111/j.1574-6968.1993.tb06370.x

Agr-related sequences in Staphylococcus lugdunensis

François Vandenesch, Steven J. Projan, Barry Kreiswirth, Jerome Etienne, Richard P. Novick

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Sequences related to the Staphylococcus aureus accessory gene regulator (agr) were demonstrated in S. lugdunensis by Southern blot analysis of 13 strains and sequencing of the S. lugdunensis agr-like locus (agr-sl). Northern blot analysis of cellular RNA revealed the presence of a transcript having homology with the agr-P3 transcript (RNAIII) for three of the six strains tested. The three strains containing this transcript produce a hemolysin with phenotypic properties similar to that of S. aureus δ-hemolysin. Nevertheless, unlike agr-P3 from S. aureus, agr-sl does not encode any potential peptides homologous to S. aureus δ-hemolysin, suggesting that the hemolytic activity detected in S. lugdunensis is encoded elsewhere and may be controlled by agr-sl.

Original language	English (US)
Pages (from-to)	115-122
Number of pages	8
Journal	FEMS Microbiology Letters
Volume	111
Issue number	1
DOIs	https://doi.org/10.1111/j.1574-6968.1993.tb06370.x
State	Published - Jul 15 1993
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology
Molecular Biology
Genetics

Keywords

Staphylococcus aureus
Staphylococcus lugdunensis
agr
δ-hemolysin

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10.1111/j.1574-6968.1993.tb06370.x

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title = "Agr-related sequences in Staphylococcus lugdunensis",

abstract = "Sequences related to the Staphylococcus aureus accessory gene regulator (agr) were demonstrated in S. lugdunensis by Southern blot analysis of 13 strains and sequencing of the S. lugdunensis agr-like locus (agr-sl). Northern blot analysis of cellular RNA revealed the presence of a transcript having homology with the agr-P3 transcript (RNAIII) for three of the six strains tested. The three strains containing this transcript produce a hemolysin with phenotypic properties similar to that of S. aureus δ-hemolysin. Nevertheless, unlike agr-P3 from S. aureus, agr-sl does not encode any potential peptides homologous to S. aureus δ-hemolysin, suggesting that the hemolytic activity detected in S. lugdunensis is encoded elsewhere and may be controlled by agr-sl.",

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author = "Fran{\c c}ois Vandenesch and Projan, {Steven J.} and Barry Kreiswirth and Jerome Etienne and Novick, {Richard P.}",

note = "Funding Information: We thankP rof. Jean Fleurettefo r providingS . lugdunensis isolates, Sorraya Moghazeh and Yvonne B6nito for technicasl upportsa, nd Harriet Marasco for editorial guidanceT. his work was supportedb y Grant AI30138-02f rom the National Instituteo f Health (USA) to R.P.N., and by a grant from the Conseil R6gional Rh6ne-Alpe(sL yon,F rance)t o F.V.",

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AU - Projan, Steven J.

AU - Kreiswirth, Barry

AU - Etienne, Jerome

AU - Novick, Richard P.

N1 - Funding Information: We thankP rof. Jean Fleurettefo r providingS . lugdunensis isolates, Sorraya Moghazeh and Yvonne B6nito for technicasl upportsa, nd Harriet Marasco for editorial guidanceT. his work was supportedb y Grant AI30138-02f rom the National Instituteo f Health (USA) to R.P.N., and by a grant from the Conseil R6gional Rh6ne-Alpe(sL yon,F rance)t o F.V.

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N2 - Sequences related to the Staphylococcus aureus accessory gene regulator (agr) were demonstrated in S. lugdunensis by Southern blot analysis of 13 strains and sequencing of the S. lugdunensis agr-like locus (agr-sl). Northern blot analysis of cellular RNA revealed the presence of a transcript having homology with the agr-P3 transcript (RNAIII) for three of the six strains tested. The three strains containing this transcript produce a hemolysin with phenotypic properties similar to that of S. aureus δ-hemolysin. Nevertheless, unlike agr-P3 from S. aureus, agr-sl does not encode any potential peptides homologous to S. aureus δ-hemolysin, suggesting that the hemolytic activity detected in S. lugdunensis is encoded elsewhere and may be controlled by agr-sl.

AB - Sequences related to the Staphylococcus aureus accessory gene regulator (agr) were demonstrated in S. lugdunensis by Southern blot analysis of 13 strains and sequencing of the S. lugdunensis agr-like locus (agr-sl). Northern blot analysis of cellular RNA revealed the presence of a transcript having homology with the agr-P3 transcript (RNAIII) for three of the six strains tested. The three strains containing this transcript produce a hemolysin with phenotypic properties similar to that of S. aureus δ-hemolysin. Nevertheless, unlike agr-P3 from S. aureus, agr-sl does not encode any potential peptides homologous to S. aureus δ-hemolysin, suggesting that the hemolytic activity detected in S. lugdunensis is encoded elsewhere and may be controlled by agr-sl.

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Agr-related sequences in Staphylococcus lugdunensis

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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