airway smooth muscle and airway hyperresponsiveness in asthma: mechanisms of airway smooth muscle dysfunction

Eric B. Gebski; Omkar Anaspure; Reynold A. Panettieri; Cynthia J. Koziol-White

doi:10.23736/S0026-4806.21.07283-9

airway smooth muscle and airway hyperresponsiveness in asthma: mechanisms of airway smooth muscle dysfunction

Eric B. Gebski, Omkar Anaspure, Reynold A. Panettieri, Cynthia J. Koziol-White

Rutgers Institute for Translational Medicine and Science

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

airway smooth muscle plays a pivotal role in modulating bronchomotor tone. Modulation of contractile and relaxation signaling is critical to alleviate the airway hyperresponsiveness (aHr) associated with asthma. emerging studies examining the phenotype of aSM in the context of asthma provide rich avenues to develop more effective therapeutics to attenuate the aHr associated with the disease.

Original language	English (US)
Pages (from-to)	4-16
Number of pages	13
Journal	Minerva Medica
Volume	113
Issue number	1
DOIs	https://doi.org/10.23736/S0026-4806.21.07283-9
State	Published - Feb 2022

All Science Journal Classification (ASJC) codes

General Medicine

Keywords

Bronchoconstriction
Bronchodilator agents
asthma

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10.23736/S0026-4806.21.07283-9

Cite this

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title = "airway smooth muscle and airway hyperresponsiveness in asthma: mechanisms of airway smooth muscle dysfunction",

abstract = "airway smooth muscle plays a pivotal role in modulating bronchomotor tone. Modulation of contractile and relaxation signaling is critical to alleviate the airway hyperresponsiveness (aHr) associated with asthma. emerging studies examining the phenotype of aSM in the context of asthma provide rich avenues to develop more effective therapeutics to attenuate the aHr associated with the disease.",

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AU - Anaspure, Omkar

AU - Panettieri, Reynold A.

AU - Koziol-White, Cynthia J.

PY - 2022/2

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N2 - airway smooth muscle plays a pivotal role in modulating bronchomotor tone. Modulation of contractile and relaxation signaling is critical to alleviate the airway hyperresponsiveness (aHr) associated with asthma. emerging studies examining the phenotype of aSM in the context of asthma provide rich avenues to develop more effective therapeutics to attenuate the aHr associated with the disease.

AB - airway smooth muscle plays a pivotal role in modulating bronchomotor tone. Modulation of contractile and relaxation signaling is critical to alleviate the airway hyperresponsiveness (aHr) associated with asthma. emerging studies examining the phenotype of aSM in the context of asthma provide rich avenues to develop more effective therapeutics to attenuate the aHr associated with the disease.

KW - Bronchoconstriction

KW - Bronchodilator agents

KW - asthma

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airway smooth muscle and airway hyperresponsiveness in asthma: mechanisms of airway smooth muscle dysfunction

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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