Airway smooth muscle and immunomodulation in acute exacerbations of airway disease

Cynthia J. Koziol-White, Reynold A. Panettieri

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Airway smooth muscle (ASM) manifests a hyperresponsive phenotype in airway disorders such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Current evidence also suggests that ASM modulates immune responses by secreting mediators and expressing cell surface molecules. Such processes amplify or dampen inflammation by inflammatory cells in the airways or by altering cellular responses to viruses, bacteria, or pathogens known to exacerbate airways diseases.

Original languageEnglish (US)
Pages (from-to)178-185
Number of pages8
JournalImmunological Reviews
Volume242
Issue number1
DOIs
StatePublished - Jul 2011

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Keywords

  • Airway hyperresponsiveness
  • Cytokines
  • Inflammation
  • Toll-like receptors
  • Viral disorder

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