Airway smooth muscle: Immunomodulatory cells?

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Evidence suggests that airway smooth muscle, the most important cell modulating bronchomotor tone, plays an important immunomodulatory role in the orchestration and perpetuation of airway inflammation. The signaling pathways that modulate leukocyte function may be disparate from those found in resident effector cells such as airway smooth muscle, fibroblasts, and epithelial cells. Further investigation and understanding of the pivotal signaling pathways that modulate airway smooth muscle cell release, secretion of chemokines/cytokines, and expression of cell adhesion molecules may offer new therapeutic approaches in the treatment of asthma.

Original languageEnglish (US)
Pages (from-to)381-386
Number of pages6
JournalAllergy and Asthma Proceedings
Issue number6
StatePublished - Nov 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


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