Airway smooth muscle in bronchial tone, inflammation, and remodeling: Basic knowledge to clinical relevance

Reynold A. Panettieri, Michael I. Kotlikoff, William T. Gerthoffer, Marc B. Hershenson, Prescott G. Woodruff, Ian P. Hall, Susan Banks-Schlegel

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations


Airway smooth muscle (ASM) plays a pivotal role in modulating bronchomotor tone but also orchestrates and perpetuates airway inflammation and remodeling. Despite substantial research, there remain important unanswered questions. In 2006, the National Heart, Lung, and Blood Institute sponsored a workshop to define new directions in ASM biology. Important questions concerning the key functions of ASM include the following: Does developmental dysregulation of ASM function promote airway disease, what key signaling pathways in ASM evoke airway hyperresponsiveness in vivo, do alterations in ASM mass affect excitation-contraction coupling, and can ASM modulate airway inflammation and remodeling in a physiologically relevant manner? This workshop identified critical issues in ASM biology to delineate areas for scientific investigation in the identification of new therapeutic and diagnostic approaches in asthma, chronic obstructive pulmonary disease, and cystic fibrosis.

Original languageEnglish (US)
Pages (from-to)248-252
Number of pages5
JournalAmerican journal of respiratory and critical care medicine
Issue number3
StatePublished - Feb 1 2008

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


  • Force generation
  • Migration
  • Myocyte
  • Remodeling
  • Signal transduction


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