Aldose reductase inhibition by ponalrestat (statil) does not prevent proteinuria in long-term diabetic rats

A. S. Reddi, G. N. Jyothirmayi

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The aldose reductase pathway has been implicated in the development of chronic complications of diabetes. In this study, we investigated the effect of an aldose reductase inhibitor, statil, on glomerular synthesis of heparan sulfate and albuminuria in male Wistar rats made diabetic with streptozotocin. Heparan sulfate is the predominant glycosaminoglycan (GAG) proteoglycan in the glomerular basement membrane (GBM). It confers a negative charge on the GBM, and its loss has been related to the presence of albumin in the urine. Diabetic rats synthesized less glomerular heparan sulfate and excreted more albumin than normal rats. Glomerular sorbitol concentration was significantly higher in diabetic than in normal rats. Chronic treatment of diabetic rats with statil did not improve either heparan sulfate synthesis or albuminuria despite normalization of glomerular sorbitol content. The present study does not support the role of excess sorbitol in the development of glomerular abnormalities in this rat model of streptozotocin diabetes.

Original languageEnglish (US)
Pages (from-to)233-240
Number of pages8
JournalJournal of Diabetes and Its Complications
Volume7
Issue number4
DOIs
StatePublished - Jan 1 1993

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Aldose reductase inhibition by ponalrestat (statil) does not prevent proteinuria in long-term diabetic rats'. Together they form a unique fingerprint.

Cite this