Allogeneic Versus Autologous Stem Cell Transplantation in Regenerative Medicine

Katarzyna A. Trzaska-Accurso, Pranela Rameshwar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The choice of allogeneic or autologous stem cells as cellular therapy is not a simple one since the impact of this choice goes beyond the simple issue of preventing rejection of the implanted stem cells. Ultimately, the goal is to treat with stem cells; moreover, in the case of allogeneic stem cells, the goal is to also safely and efficiently achieve chimera. In the case of mesenchymal stem cells, though these cells have unique immune properties, there are confounds that still to date need to be addressed. These issues are discussed in this chapter, comprising both the immune-enhancing role of these cells as well as their ability to support tumour growth. Despite the vast existing knowledge of bone marrow transplantation and the history of success in achieving chimera in the clinic, the challenges of using stem cells for different purposes remain large since the biological basis of this novel modality of treatment of disease may be dramatically different from that implemented to reconstitute the haematopoietic system by simple bone marrow transplantation. Nonetheless, much can be leant from the expertise of those involved in bone marrow transplantation, including not only technical aspects but also epidemiological ones. Finally, regardless of whether cells are from autologous or allogeneic source, transformation remains a critical issue since the stem cells used in therapy are placed in a microenvironment that can potentiate proliferation.

Original languageEnglish (US)
Title of host publicationStem Cells in Regenerative Medicine
Subtitle of host publicationScience, Regulation and Business Strategies
PublisherWiley-Blackwell
Pages487-496
Number of pages10
ISBN (Electronic)9781118846193
ISBN (Print)9781119971399
DOIs
StatePublished - Nov 4 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • Allogeneic stem cell transplantation
  • Autologous stem cell transplantation
  • Embryonic stem cells
  • Haematopoietic stem cell transplantation
  • Mesenchymal stem cells
  • Regenerative medicine
  • Stem cell therapy

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