Alteration in thermal sensitivity of Chinese hamster cells by D2O treatment

E. I. Azzam; I. George; G. P. Raaphorst

doi:10.2307/3575742

Alteration in thermal sensitivity of Chinese hamster cells by D₂O treatment

E. I. Azzam, I. George, G. P. Raaphorst

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Abstract

Chinese hamster V79 cells were maintained at temperatures between 40.5 and 46.0°C in normal culture medium or medium containing 87% D₂O. Between 40.5 and 42.0° C, thermal sensitization was observed in D₂O medium for heating intervals greater than 4 to 6 hr, and thermal tolerance was eliminated. Heating between 43.0 and 46.0°C in D₂O medium resulted in thermal protection. Arrhenius curves showed a break at about 43.0°C for cells heated in normal medium, but not for cells heated in D₂O medium.

Original language	English (US)
Pages (from-to)	644-648
Number of pages	5
Journal	Radiation Research
Volume	90
Issue number	3
DOIs	https://doi.org/10.2307/3575742
State	Published - 1982
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Radiation
Radiology Nuclear Medicine and imaging

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title = "Alteration in thermal sensitivity of Chinese hamster cells by D2O treatment",

abstract = "Chinese hamster V79 cells were maintained at temperatures between 40.5 and 46.0°C in normal culture medium or medium containing 87% D2O. Between 40.5 and 42.0° C, thermal sensitization was observed in D2O medium for heating intervals greater than 4 to 6 hr, and thermal tolerance was eliminated. Heating between 43.0 and 46.0°C in D2O medium resulted in thermal protection. Arrhenius curves showed a break at about 43.0°C for cells heated in normal medium, but not for cells heated in D2O medium.",

author = "Azzam, {E. I.} and I. George and Raaphorst, {G. P.}",

year = "1982",

doi = "10.2307/3575742",

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pages = "644--648",

journal = "Radiation Research",

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AU - Azzam, E. I.

AU - George, I.

AU - Raaphorst, G. P.

PY - 1982

Y1 - 1982

N2 - Chinese hamster V79 cells were maintained at temperatures between 40.5 and 46.0°C in normal culture medium or medium containing 87% D2O. Between 40.5 and 42.0° C, thermal sensitization was observed in D2O medium for heating intervals greater than 4 to 6 hr, and thermal tolerance was eliminated. Heating between 43.0 and 46.0°C in D2O medium resulted in thermal protection. Arrhenius curves showed a break at about 43.0°C for cells heated in normal medium, but not for cells heated in D2O medium.

AB - Chinese hamster V79 cells were maintained at temperatures between 40.5 and 46.0°C in normal culture medium or medium containing 87% D2O. Between 40.5 and 42.0° C, thermal sensitization was observed in D2O medium for heating intervals greater than 4 to 6 hr, and thermal tolerance was eliminated. Heating between 43.0 and 46.0°C in D2O medium resulted in thermal protection. Arrhenius curves showed a break at about 43.0°C for cells heated in normal medium, but not for cells heated in D2O medium.

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JF - Radiation Research

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ER -

Alteration in thermal sensitivity of Chinese hamster cells by D₂O treatment

Abstract

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