Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies

Coeli M.B. Lopes, Hailin Zhang, Tibor Rohacs, Taihao Jin, Jian Yang, Diomedes E. Logothetis

Research output: Contribution to journalArticlepeer-review

316 Scopus citations

Abstract

Inwardly rectifying K+ (Kir) channels are important regulators of resting membrane potential and cell excitability. The activity of Kir channels is critically dependent on the integrity of channel interactions with phosphatidylinositol 4,5-bisphosphate (PIP2). Here we identify and characterize channel-PIP2 interactions that are conserved among Kir family members. We find basic residues that interact with PIP2, two of which have been associated with Andersen's and Bartter's syndromes. We show that several naturally occurring mutants decrease channel-PIP2 interactions, leading to disease.

Original languageEnglish (US)
Pages (from-to)933-944
Number of pages12
JournalNeuron
Volume34
Issue number6
DOIs
StatePublished - Jun 13 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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