TY - JOUR
T1 - Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patient
AU - Eidson, Maggie
AU - Wahlstrom, Justin
AU - Beaulieu, Aimee M.
AU - Zaidi, Bushra
AU - Carsons, Steven E.
AU - Crow, Peggy K.
AU - Yuan, Jianda
AU - Wolchok, Jedd D.
AU - Horsthemke, Bernhard
AU - Wieczorek, Dagmar
AU - Sant'Angelo, Derek B.
PY - 2011
Y1 - 2011
N2 - In mice, the transcription factor, PLZF, controls the development of effector functions in invariant NKT cells and a subset of NKT cell-like, γδ T cells. Here, we show that in human lymphocytes, in addition to invariant NKT cells, PLZF was also expressed in a large percentage of CD8+ and CD4+ T cells. Furthermore, PLZF was also found to be expressed in all γδ T cells and in all NK cells. Importantly, we show that in a donor lacking functional PLZF, all of these various lymphocyte populations were altered. Therefore, in contrast to mice, PLZF appears to control the development and/or function of a wide variety of human lymphocytes that represent more than 10% of the total PBMCs. Interestingly, the PLZF-expressing CD8+ T cell population was found to be expanded in the peripheral blood of patients with metastatic melanoma but was greatly diminished in patients with autoimmune disease.
AB - In mice, the transcription factor, PLZF, controls the development of effector functions in invariant NKT cells and a subset of NKT cell-like, γδ T cells. Here, we show that in human lymphocytes, in addition to invariant NKT cells, PLZF was also expressed in a large percentage of CD8+ and CD4+ T cells. Furthermore, PLZF was also found to be expressed in all γδ T cells and in all NK cells. Importantly, we show that in a donor lacking functional PLZF, all of these various lymphocyte populations were altered. Therefore, in contrast to mice, PLZF appears to control the development and/or function of a wide variety of human lymphocytes that represent more than 10% of the total PBMCs. Interestingly, the PLZF-expressing CD8+ T cell population was found to be expanded in the peripheral blood of patients with metastatic melanoma but was greatly diminished in patients with autoimmune disease.
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U2 - 10.1371/journal.pone.0024441
DO - 10.1371/journal.pone.0024441
M3 - Article
C2 - 21915328
AN - SCOPUS:80052432708
VL - 6
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 9
M1 - e24441
ER -