Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patient

Maggie Eidson, Justin Wahlstrom, Aimee M. Beaulieu, Bushra Zaidi, Steven E. Carsons, Peggy K. Crow, Jianda Yuan, Jedd D. Wolchok, Bernhard Horsthemke, Dagmar Wieczorek, Derek B. Sant'Angelo

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

In mice, the transcription factor, PLZF, controls the development of effector functions in invariant NKT cells and a subset of NKT cell-like, γδ T cells. Here, we show that in human lymphocytes, in addition to invariant NKT cells, PLZF was also expressed in a large percentage of CD8+ and CD4+ T cells. Furthermore, PLZF was also found to be expressed in all γδ T cells and in all NK cells. Importantly, we show that in a donor lacking functional PLZF, all of these various lymphocyte populations were altered. Therefore, in contrast to mice, PLZF appears to control the development and/or function of a wide variety of human lymphocytes that represent more than 10% of the total PBMCs. Interestingly, the PLZF-expressing CD8+ T cell population was found to be expanded in the peripheral blood of patients with metastatic melanoma but was greatly diminished in patients with autoimmune disease.

Original languageEnglish (US)
Article numbere24441
JournalPloS one
Volume6
Issue number9
DOIs
StatePublished - 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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