Altered pain modulation to noxious heat thermal stimuli in burning mouth syndrome

Chisa Nishihara, Kosuke Watanabe, Kana Ozasa, Junad Khan, Eli Eliav, Yoshiki Imamura, Noboru Noma

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objectives: The aim of this study was to examine temporal summation (TS) and conditioned pain modulation (CPM) in patients with burning mouth syndrome (BMS) and healthy controls using intra-epidermal electrical stimulation (IES). Materials and Methods: Twenty-six female patients with BMS and 27 healthy female controls participated in this study. A single stimulus with electrical stimulation followed by a train of 10 successive stimuli was administered to the right chin of participants in both the BMS and control groups. CPM was evaluated with the changes of TS calculated from the difference in numerical pain scale data between these two test stimuli and the following warm (40°C) and hot (47°C) conditioning stimuli applied at the non-dominant hand in both the BMS and control groups. Results: TS was present in both the BMS and control groups. CPM in the BMS group was significantly less efficient at the 47°C condition than that in the control group, while no significant difference was observed in the CPM between the BMS and the control groups at the 40°C condition. Conclusion: These findings indicate that BMS is associated with a deficit inhibitory CPM and implicate the involvement of the central nervous system in the pathophysiology of BMS.

Original languageEnglish (US)
Pages (from-to)1777-1782
Number of pages6
JournalOral Diseases
Issue number8
StatePublished - Nov 1 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)


  • burning mouth syndrome
  • conditioned pain modulation
  • pain modulation
  • temporal summation


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