Altered terminal glycosylation and the pathophysiology of CF lung disease

Andrew D. Rhim, Lidia I. Stoykova, Arvind J. Trindade, Mary Catherine Glick, Thomas F. Scanlin

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Altered terminal glycosylation, with increased fucosylation and decreased sialylation, is a hallmark of the cystic fibrosis (CF) glycosylation phenotype. The glycosylation phenotype of CF airway epithelial cells has been modulated by the expression of wtCFTR. Understanding the effects of mutant CFTR on glycosylation may provide further insight into the regulation of glycoconjugate processing as well as new approaches to the therapy of CF.

Original languageEnglish (US)
Pages (from-to)95-96
Number of pages2
JournalJournal of Cystic Fibrosis
Issue numberSUPPL. 2
StatePublished - Aug 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine


  • CFTR
  • Cystic fibrosis
  • Fucosylation
  • Golgi
  • Terminal glycosylation


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