Altered terminal glycosylation, with increased fucosylation and decreased sialylation, is a hallmark of the cystic fibrosis (CF) glycosylation phenotype. The glycosylation phenotype of CF airway epithelial cells has been modulated by the expression of wtCFTR. Understanding the effects of mutant CFTR on glycosylation may provide further insight into the regulation of glycoconjugate processing as well as new approaches to the therapy of CF.
All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Pulmonary and Respiratory Medicine
- Cystic fibrosis
- Terminal glycosylation