Alternative mitophagy is a major form of mitophagy in the chronically stressed heart

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Abstract

Mitochondrial dysfunction is a key determinant of the development of cardiomyopathy in patients with obesity and diabetes. We recently reported that mitophagy is activated in the mouse heart during the chronic phase of high-fat diet (HFD) consumption, despite downregulation of general macroautophagy/autophagy. This form of mitophagy is mediated by a mechanism distinct from that of conventional autophagy and is termed alternative mitophagy. We here discuss the underlying mechanisms of alternative mitophagy and its functional significance in heart disease.

Original languageEnglish (US)
Pages (from-to)2252-2253
Number of pages2
JournalAutophagy
Volume18
Issue number9
DOIs
StatePublished - 2022

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Keywords

  • Mitophagy
  • Rab9
  • cardiomyopathy
  • diabetes
  • heart
  • obesity

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