Alternative Pre-mRNA Splicing of Mu Opioid Receptor Gene: Molecular Mechanisms Underlying the Complex Actions of Mu Opioids

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The μ-opioid receptor (MOR) plays a fundamental role in mediating the actions of morphine and most clinical analgesic agents, as well as drugs of abuse such as heroin. Clinically, patients often display diverse responses toward various mu opioids, including analgesia, tolerance, and side effects, such as constipation, itch, and addiction. Alternative pre-mRNA splicing is a major mechanism for creating protein isoform diversity. Alternative pre-mRNA splicing can process pre-mRNA in multiple ways to produce different mature mRNAs. Evolution of the OPRM1 alternative splicing in the mammalian species highlights the special place of the OPRM1 gene in the opioid receptor gene family. Extensive alternative splicing of the OPRM1 gene creates not only RNA and protein diversity but also functional complexity demonstrated by various C-terminal full-length variants and truncated 6-TM variants.

Original languageEnglish (US)
Title of host publicationPain Genetics
Subtitle of host publicationBasic to Translational Science
PublisherWiley-Blackwell
Pages79-98
Number of pages20
ISBN (Electronic)9781118398890
ISBN (Print)9781118398845
DOIs
StatePublished - Nov 25 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • Alternative Pre-mRNA splicing
  • Mu Opioids
  • OPRM1 gene
  • μ-opioid receptor (MOR)

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