American Radium Society (ARS) Appropriate Use Criteria (AUC) for Extrahepatic Cholangiocarcinoma

Leila T. Tchelebi, Krishan R. Jethwa, Anna T. Levy, Christopher J. Anker, Timothy Kennedy, Elliot Grodstein, Christopher L. Hallemeier, Salma K. Jabbour, Ed Kim, Rachit Kumar, Percy Lee, William Small, Vonetta M. Williams, Navesh Sharma, Suzanne Russo

Research output: Contribution to journalArticlepeer-review


Although uncommon, extrahepatic cholangiocarcinoma (EHCC) is a deadly malignancy, and the treatment approaches remain controversial. While surgery remains the only cure, few patients are candidates for resection up front, and there are high rates of both local and distant failure following resection. Herein, we systematically review the available evidence regarding treatment approaches for patients with EHCC, including surgery, radiation, and chemotherapy. The evidence regarding treatment outcomes was assessed using the Population, Intervention, Comparator, Outcome, and Study design (PICOS) framework. A summary of recommendations based on the available literature is outlined for specific clinical scenarios encountered by providers in the clinic to guide the management of these patients.

Original languageEnglish (US)
Pages (from-to)73-84
Number of pages12
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Issue number2
StatePublished - Feb 1 2023

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


  • Extrahepatic cholangiocarcinoma
  • chemotherapy
  • liver transplant
  • radiation therapy
  • surgery


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