Ammonificins C and D, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans

Eric H. Andrianasolo; Liti Haramaty; Richard Rosario-Passapera; Costantino Vetriani; Paul Falkowski; Eileen White; Richard Lutz

doi:10.3390/md10102300

Ammonificins C and D, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans

Eric H. Andrianasolo, Liti Haramaty, Richard Rosario-Passapera, Costantino Vetriani, Paul Falkowski, Eileen White, Richard Lutz

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17 Scopus citations

Abstract

Chemical and biological investigation of the cultured marine hydrothermal vent bacterium, Thermovibrio ammonifican led to the isolation of two hydroxyethylamine chromene derivatives, ammonificins C and D. Their structures were elucidated using combination of NMR and mass spectrometry. Absolute stereochemistry was ascertained by comparison of experimental and calculated CD spectra. Biological evaluation and assessment were determined using the patented ApopScreen cell-based screen for apoptosis-induction. Ammonificins C and D induce apoptosis in micromolar concentrations. To our knowledge, this finding is the first report of chemical compounds that induce apoptosis from the cultured deep-sea marine organism, hydrothermal vent bacterium, Thermovibrio ammonificans.

Original language	English (US)
Pages (from-to)	2300-2311
Number of pages	12
Journal	Marine Drugs
Volume	10
Issue number	10
DOIs	https://doi.org/10.3390/md10102300
State	Published - Oct 2012

All Science Journal Classification (ASJC) codes

Drug Discovery

Keywords

Bacteria
Computational methods
Deep-sea hydrothermal vent
Drug discovery
Induction of apoptosis
Marine natural product

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10.3390/md10102300

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title = "Ammonificins C and D, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans",

abstract = "Chemical and biological investigation of the cultured marine hydrothermal vent bacterium, Thermovibrio ammonifican led to the isolation of two hydroxyethylamine chromene derivatives, ammonificins C and D. Their structures were elucidated using combination of NMR and mass spectrometry. Absolute stereochemistry was ascertained by comparison of experimental and calculated CD spectra. Biological evaluation and assessment were determined using the patented ApopScreen cell-based screen for apoptosis-induction. Ammonificins C and D induce apoptosis in micromolar concentrations. To our knowledge, this finding is the first report of chemical compounds that induce apoptosis from the cultured deep-sea marine organism, hydrothermal vent bacterium, Thermovibrio ammonificans.",

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T1 - Ammonificins C and D, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans

AU - Andrianasolo, Eric H.

AU - Haramaty, Liti

AU - Rosario-Passapera, Richard

AU - Vetriani, Costantino

AU - Falkowski, Paul

AU - White, Eileen

AU - Lutz, Richard

PY - 2012/10

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AB - Chemical and biological investigation of the cultured marine hydrothermal vent bacterium, Thermovibrio ammonifican led to the isolation of two hydroxyethylamine chromene derivatives, ammonificins C and D. Their structures were elucidated using combination of NMR and mass spectrometry. Absolute stereochemistry was ascertained by comparison of experimental and calculated CD spectra. Biological evaluation and assessment were determined using the patented ApopScreen cell-based screen for apoptosis-induction. Ammonificins C and D induce apoptosis in micromolar concentrations. To our knowledge, this finding is the first report of chemical compounds that induce apoptosis from the cultured deep-sea marine organism, hydrothermal vent bacterium, Thermovibrio ammonificans.

KW - Bacteria

KW - Computational methods

KW - Deep-sea hydrothermal vent

KW - Drug discovery

KW - Induction of apoptosis

KW - Marine natural product

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Ammonificins C and D, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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