Ammonificins C and D, hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans

Eric H. Andrianasolo, Liti Haramaty, Richard Rosario-Passapera, Costantino Vetriani, Paul Falkowski, Eileen White, Richard Lutz

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Chemical and biological investigation of the cultured marine hydrothermal vent bacterium, Thermovibrio ammonifican led to the isolation of two hydroxyethylamine chromene derivatives, ammonificins C and D. Their structures were elucidated using combination of NMR and mass spectrometry. Absolute stereochemistry was ascertained by comparison of experimental and calculated CD spectra. Biological evaluation and assessment were determined using the patented ApopScreen cell-based screen for apoptosis-induction. Ammonificins C and D induce apoptosis in micromolar concentrations. To our knowledge, this finding is the first report of chemical compounds that induce apoptosis from the cultured deep-sea marine organism, hydrothermal vent bacterium, Thermovibrio ammonificans.

Original languageEnglish (US)
Pages (from-to)2300-2311
Number of pages12
JournalMarine Drugs
Volume10
Issue number10
DOIs
StatePublished - Oct 2012

All Science Journal Classification (ASJC) codes

  • Drug Discovery

Keywords

  • Bacteria
  • Computational methods
  • Deep-sea hydrothermal vent
  • Drug discovery
  • Induction of apoptosis
  • Marine natural product

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