AMPK mediates autophagy during myocardial ischemia in vivo

Hiromitsu Takagi, Yutaka Matsui, Shinichi Hirotani, Hideyuki Sakoda, Tomoichiro Asano, Junichi Sadoshima

Research output: Contribution to journalArticlepeer-review

120 Scopus citations

Abstract

We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.

Original languageEnglish (US)
Pages (from-to)405-407
Number of pages3
JournalAutophagy
Volume3
Issue number4
DOIs
StatePublished - 2007

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Keywords

  • AMPK
  • Autophagy
  • Beclin1
  • Heart
  • Ischemia
  • Reperfusion

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