AMPK mediates autophagy during myocardial ischemia in vivo

Hiromitsu Takagi; Yutaka Matsui; Shinichi Hirotani; Hideyuki Sakoda; Tomoichiro Asano; Junichi Sadoshima

doi:10.4161/auto.4281

AMPK mediates autophagy during myocardial ischemia in vivo

Hiromitsu Takagi, Yutaka Matsui, Shinichi Hirotani, Hideyuki Sakoda, Tomoichiro Asano, Junichi Sadoshima

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.

Original language	English (US)
Pages (from-to)	405-407
Number of pages	3
Journal	Autophagy
Volume	3
Issue number	4
DOIs	https://doi.org/10.4161/auto.4281
State	Published - 2007

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

Keywords

AMPK
Autophagy
Beclin1
Heart
Ischemia
Reperfusion

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10.4161/auto.4281

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title = "AMPK mediates autophagy during myocardial ischemia in vivo",

abstract = "We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.",

keywords = "AMPK, Autophagy, Beclin1, Heart, Ischemia, Reperfusion",

author = "Hiromitsu Takagi and Yutaka Matsui and Shinichi Hirotani and Hideyuki Sakoda and Tomoichiro Asano and Junichi Sadoshima",

year = "2007",

doi = "10.4161/auto.4281",

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volume = "3",

pages = "405--407",

journal = "Autophagy",

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T1 - AMPK mediates autophagy during myocardial ischemia in vivo

AU - Takagi, Hiromitsu

AU - Matsui, Yutaka

AU - Hirotani, Shinichi

AU - Sakoda, Hideyuki

AU - Asano, Tomoichiro

AU - Sadoshima, Junichi

PY - 2007

Y1 - 2007

N2 - We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.

AB - We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.

KW - AMPK

KW - Autophagy

KW - Beclin1

KW - Heart

KW - Ischemia

KW - Reperfusion

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M3 - Article

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AN - SCOPUS:34250802633

SN - 1554-8627

VL - 3

SP - 405

EP - 407

JO - Autophagy

JF - Autophagy

IS - 4

ER -

AMPK mediates autophagy during myocardial ischemia in vivo

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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