Amplification and chromosomal dispersion of human endogenous retroviral sequences

P. E. Steele, M. A. Martin, A. B. Rabson, T. Bryan, S. J. O'Brien

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Endogenous retroviral sequences in humans have undergone amplification events involving both viral and flanking cellular sequences. We cloned members of an amplified family of full-length endogenous retroviral sequences. Genomic blotting, employing a flanking cellular DNA probe derived from a member of this family, revealed a similar array of reactive bands in both humans and chimpanzees, indicating that an amplification event involving retroviral and associated cellular DNA sequences occurred before the evolutionary separation of these two primates. Southern analyses of restricted somatic cell hybrid DNA preparations suggested that endogenous retroviral segments are widely dispersed in the human genome and that amplification and dispersion events may be linked.

Original languageEnglish (US)
Pages (from-to)545-550
Number of pages6
JournalJournal of virology
Issue number3
StatePublished - 1986
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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