Amygdala microcircuits controlling learned fear

Sevil Duvarci, Denis Pare

Research output: Contribution to journalReview articlepeer-review

349 Scopus citations

Abstract

We review recent work on the role of intrinsic amygdala networks in the regulation of classically conditioned defensive behaviors, commonly known as conditioned fear. These new developments highlight how conditioned fear depends on far more complex networks than initially envisioned. Indeed, multiple parallel inhibitory and excitatory circuits are differentially recruited during the expression versus extinction of conditioned fear. Moreover, shifts between expression and extinction circuits involve coordinated interactions with different regions of the medial prefrontal cortex. However, key areas of uncertainty remain, particularly with respect to the connectivity of the different cell types. Filling these gaps in our knowledge is important because much evidence indicates that human anxiety disorders results from an abnormal regulation of the networks supporting fear learning. Duvarci and Pare review recent work on the role of intrinsic amygdala networks in regulating conditioned fear, revealing that it depends on multiple parallel inhibitory and excitatory circuits that are differentially recruited during the expression versus extinction of conditioned fear.

Original languageEnglish (US)
Pages (from-to)966-980
Number of pages15
JournalNeuron
Volume82
Issue number5
DOIs
StatePublished - Jun 4 2014

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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