An arylsulfatase A variant in schizophrenic patients: Preliminary report

Paul Manowitz, L. Goldstein, R. Nora

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Abstract

One of the main findings of this research is that there are some schizophrenics who have ASA specific activities which are intermediate between those of adult metachromatic leukodystrophy (MID) patients and heterozygotes for MLD. In addition, these same schizophrenics have an ASA with an abnormal electrophoretic mobility. One proposed mechanism is that the intermediate ASA specific activities are due to an inherited amino acid substitution in the protein backbone of the enzyme, which results in its abnormal electrophoretic mobility and lower activity. This is the first report of a variant form of ASA in schizophrenic patients. It remains to be demonstrated whether this particular variant will be found more frequently in schizophrenic patients, nonschizophrenic psychiatric patients, or normal controls.

Original languageEnglish (US)
Pages (from-to)1107-1113
Number of pages7
JournalBiological Psychiatry
Volume16
Issue number11
Publication statusPublished - Dec 1 1981

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All Science Journal Classification (ASJC) codes

  • Biological Psychiatry

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